PMID- 20707763
OWN - NLM
STAT- MEDLINE
DCOM- 20101001
LR  - 20220408
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Print)
IS  - 0277-0903 (Linking)
VI  - 47
IP  - 7
DP  - 2010 Sep
TI  - Association of childhood obesity with atopic and nonatopic asthma: results from 
      the National Health and Nutrition Examination Survey 1999-2006.
PG  - 822-9
LID - 10.3109/02770903.2010.489388 [doi]
AB  - BACKGROUND: Obesity and asthma prevalence have both risen among children over the 
      last several decades, and research efforts increasingly suggest that obesity is 
      associated with asthma. Some, but not all, studies have shown that the effect of 
      obesity on asthma is stronger among nonatopic individuals than among those with 
      atopy. Systemic inflammation may be a factor in this relationship. OBJECTIVE: To 
      examine the association of obesity with atopic and nonatopic asthma among U.S. 
      children and to assess the role of C-reactive protein. DESIGN: Nationally 
      representative data from the National Health and Nutrition Examination Survey 
      (NHANES) were used to examine the relationship of weight to current asthma using 
      logistic regression. Overweight was defined as >/= 85th percentile of body mass 
      index (BMI)-for-age and obesity was defined as >/= 95th percentile of BMI-for-age. 
      The presence of at least one positive allergen-specific immunoglobulin E (IgE) 
      was used to stratify the relationship by atopic status in 2005-2006 data (n = 
      3387). Setting and Participants. Stratified, multistage probability sampling was 
      used to identify survey participants. This analysis includes children ages 2-19 
      (n = 16,074) from the 1999-2006 NHANES who have information on BMI and current 
      asthma. MAIN OUTCOME MEASURE: Self-report of doctor-diagnosed current asthma. 
      RESULTS: Obesity was significantly related to current asthma among children and 
      adolescents (odds ratio [OR]: 1.68, 95% confidence interval [CI]: 1.33, 2.12). 
      The association was stronger in nonatopic children (OR: 2.46, 95% CI: 1.21, 5.02) 
      than in atopic children (OR: 1.34, 95% CI: 0.70, 2.57) (interaction p value = 
      .09). C-reactive protein levels were associated with current asthma in nonatopic 
      children, but not after adjusting for BMI. CONCLUSION: Excess weight in children 
      is associated with higher rates of asthma, especially asthma that is not 
      accompanied by allergic disease.
FAU - Visness, Cynthia M
AU  - Visness CM
AD  - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC 27517, U.S.A. cindy_visness@rhoworld.com
FAU - London, Stephanie J
AU  - London SJ
FAU - Daniels, Julie L
AU  - Daniels JL
FAU - Kaufman, Jay S
AU  - Kaufman JS
FAU - Yeatts, Karin B
AU  - Yeatts KB
FAU - Siega-Riz, Anna-Maria
AU  - Siega-Riz AM
FAU - Calatroni, Agustin
AU  - Calatroni A
FAU - Zeldin, Darryl C
AU  - Zeldin DC
LA  - eng
GR  - P30 ES010126/ES/NIEHS NIH HHS/United States
GR  - Z01 ES025041/ImNIH/Intramural NIH HHS/United States
GR  - N01AI25482/AI/NIAID NIH HHS/United States
GR  - N01 AI-25482/AI/NIAID NIH HHS/United States
GR  - Z01 ES025041-11/ImNIH/Intramural NIH HHS/United States
GR  - R24 HD050924/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asthma/*epidemiology
MH  - Body Mass Index
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Child, Preschool
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Obesity/*complications
MH  - Time Factors
MH  - Young Adult
PMC - PMC2975947
MID - NIHMS226613
COIS- Conflict of Interest The authors declare that they have no competing financial 
      interests related to this work
EDAT- 2010/08/17 06:00
MHDA- 2010/10/05 06:00
PMCR- 2010/11/09
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
PHST- 2010/11/09 00:00 [pmc-release]
AID - 10.3109/02770903.2010.489388 [doi]
PST - ppublish
SO  - J Asthma. 2010 Sep;47(7):822-9. doi: 10.3109/02770903.2010.489388.