PMID- 20707881
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 76
IP  - 6
DP  - 2010 Dec
TI  - Polymorphism between HLA-A*0301 and A*0302 located outside the pocket F alters 
      the POmega peptide motif.
PG  - 487-90
LID - 10.1111/j.1399-0039.2010.01547.x [doi]
AB  - The human leukocyte antigen (HLA)-A*03 group has more than 90 known members and 
      is one of the largest families of HLA class I alleles, with the most common 
      variant being HLA-A*0301. In this study, we determined the peptide-binding motif 
      of the highly frequent Sudanese allele A*0302 and compared it with the previously 
      published peptide-binding motif of A*0301. The two alleles differ only at two 
      distinct residues Glu152Val and Leu156Gln, which are predicted to be part of 
      specificity pockets D, C and E and thus in contact with the peptide. Soluble 
      recombinant A*0302 was expressed, affinity purified and the bound peptides were 
      then eluted and analysed by mass spectrometry. The peptide-binding motif of 
      A*0302 differs significantly from the previously published HLA-A*0301 and the 
      Glu152Val/Leu156Gln mismatches appear to have a significant impact on the 
      peptide-binding features of A*0302 and A*0301.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Elamin, N E
AU  - Elamin NE
AD  - Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.
FAU - Bade-Doeding, C
AU  - Bade-Doeding C
FAU - Blasczyk, R
AU  - Blasczyk R
FAU - Eiz-Vesper, B
AU  - Eiz-Vesper B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*03:01 antigen)
RN  - 0 (HLA-A3 Antigen)
RN  - 0 (Peptides)
SB  - IM
MH  - *Alleles
MH  - Amino Acid Motifs
MH  - *Amino Acid Substitution
MH  - HLA-A Antigens/*genetics/immunology
MH  - HLA-A3 Antigen
MH  - Humans
MH  - Peptides/*genetics/immunology
MH  - Sudan
EDAT- 2010/08/17 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - TAN1547 [pii]
AID - 10.1111/j.1399-0039.2010.01547.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Dec;76(6):487-90. doi: 10.1111/j.1399-0039.2010.01547.x.