PMID- 20707918
OWN - NLM
STAT- MEDLINE
DCOM- 20101011
LR  - 20211020
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 10
DP  - 2010 Aug 13
TI  - Infection with HIV and HCV enhances the release of fatty acid synthase into 
      circulation: evidence for a novel indicator of viral infection.
PG  - 92
LID - 10.1186/1471-230X-10-92 [doi]
AB  - BACKGROUND: Fatty acid synthase (FASN) is an enzyme synthesized by the liver and 
      plays an important role in lipogenesis. The present study aimed to investigate 
      whether serum FASN concentration may provide a direct link between HIV and/or HCV 
      viral infections and lipid metabolic disorders commonly observed in 
      HIV/HCV-infected patients. METHODS: We evaluated serum FASN concentration in 191 
      consecutive HIV-infected patients in the absence or presence of HCV co-infection. 
      For comparison, 102 uninfected controls were included. Metabolic and inflammatory 
      phenotype was also compared with respect to the presence of HCV co-infection. 
      RESULTS: Serum FASN concentration was significantly higher in HIV-infected 
      patients than in healthy participants and HCV co-infected patients showed higher 
      levels than those without co-infection. Levels were also affected by treatment 
      regimen, but marginally influenced by virological variables. Insulin 
      concentration was the sole variable among metabolic parameters that demonstrated 
      a significant correlation with serum FASN concentrations. Serum alanine 
      aminotransferase (ALT) values correlated significantly with serum FASN 
      concentration and provided the best discrimination with respect to the presence 
      or absence of HCV co-infection. In multivariate analysis, only ALT, monocyte 
      chemoattractant protein-1 (MCP-1) and the presence of antiretroviral treatment 
      regimen significantly contributed to explain serum FASN concentration in HIV/HCV 
      co-infected patients. CONCLUSION: Serum FASN concentration is significantly 
      increased in HIV-infected individuals. The release of FASN into the circulation 
      is further enhanced in patients who are co-infected with HCV. Subsequent studies 
      should explore the usefulness of this indicator to monitor the effect of viral 
      infections on disease progression and survival.
FAU - Aragones, Gerard
AU  - Aragones G
AD  - Centre de Recerca Biomedica, Hospital Universitari de Sant Joan, Institut 
      d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
FAU - Alonso-Villaverde, Carlos
AU  - Alonso-Villaverde C
FAU - Oliveras-Ferraros, Cristina
AU  - Oliveras-Ferraros C
FAU - Beltran-Debon, Raul
AU  - Beltran-Debon R
FAU - Rull, Anna
AU  - Rull A
FAU - Rodriguez-Sanabria, Fernando
AU  - Rodriguez-Sanabria F
FAU - Camps, Jordi
AU  - Camps J
FAU - Martin, Alejandro Vazquez
AU  - Martin AV
FAU - Menendez, Javier A
AU  - Menendez JA
FAU - Joven, Jorge
AU  - Joven J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100813
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Insulin)
RN  - EC 2.3.1.85 (Fatty Acid Synthases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Alanine Transaminase/blood
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood
MH  - Comorbidity
MH  - Disease Progression
MH  - Fatty Acid Synthases/*blood
MH  - Female
MH  - HIV/*physiology
MH  - HIV Infections/*blood/diagnosis/epidemiology
MH  - Hepacivirus/*physiology
MH  - Hepatitis C/*blood/diagnosis/epidemiology
MH  - Humans
MH  - Insulin/blood
MH  - Lipid Metabolism/physiology
MH  - Male
PMC - PMC2928758
EDAT- 2010/08/17 06:00
MHDA- 2010/10/12 06:00
PMCR- 2010/08/13
CRDT- 2010/08/17 06:00
PHST- 2009/12/09 00:00 [received]
PHST- 2010/08/13 00:00 [accepted]
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
PHST- 2010/08/13 00:00 [pmc-release]
AID - 1471-230X-10-92 [pii]
AID - 10.1186/1471-230X-10-92 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2010 Aug 13;10:92. doi: 10.1186/1471-230X-10-92.