PMID- 20708623
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20101220
IS  - 1879-0135 (Electronic)
IS  - 0020-7519 (Linking)
VI  - 41
IP  - 1
DP  - 2011 Jan
TI  - Schistosoma co-infection protects against brain pathology but does not prevent 
      severe disease and death in a murine model of cerebral malaria.
PG  - 21-31
LID - 10.1016/j.ijpara.2010.06.008 [doi]
AB  - Co-infections of helminths and malaria parasites are common in human populations 
      in most endemic areas. It has been suggested that concomitant helminth infections 
      inhibit the control of malaria parasitemia but down-modulate severe malarial 
      disease. We tested this hypothesis using a murine co-infection model of 
      schistosomiasis and cerebral malaria. C57BL/6 mice were infected with Schistosoma 
      mansoni and 8-9 weeks later, when Schistosoma infection was patent, mice were 
      co-infected with Plasmodium berghei ANKA strain. We found that a concomitant 
      Schistosoma infection increased parasitemia at the beginning of the P. berghei 
      infection. It did not protect against P. berghei-induced weight loss and 
      hypothermia, and P. berghei-mono-infected as well as S. mansoni-P. 
      berghei-co-infected animals showed a high case fatality between days 6 and 8 of 
      malarial infection. However, co-infection significantly reduced P. 
      berghei-induced brain pathology. Over 40% of the S. mansoni-P. 
      berghei-co-infected animals that died during this period were completely 
      protected against haemorrhaging, plugging of blood vessels and infiltration, 
      indicating that mortality in these animals was not related to cerebral disease. 
      Schistosoma mansoni-P. berghei-co-infected mice had elevated plasma 
      concentrations of IL-5 and IL-13 and on day 6 lower levels of IFN-gamma, IL-10, 
      monocyte chemoattractant protein-1 (MCP-1) and monokine induced by IFN-gamma (MIG) 
      than P. berghei-mono-infected mice. We conclude that in P. berghei infections, 
      disease and early death are caused by distinct pathogenic mechanisms, which 
      develop in parallel and are differentially influenced by the immune response to 
      S. mansoni. This might explain why, in co-infected mice, death could be induced 
      in the absence of brain pathology.
CI  - Copyright (c) 2010 Australian Society for Parasitology Inc. Published by Elsevier 
      Ltd. All rights reserved.
FAU - Bucher, Kirsten
AU  - Bucher K
AD  - Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany.
FAU - Dietz, Klaus
AU  - Dietz K
FAU - Lackner, Peter
AU  - Lackner P
FAU - Pasche, Bastian
AU  - Pasche B
FAU - Fendel, Rolf
AU  - Fendel R
FAU - Mordmuller, Benjamin
AU  - Mordmuller B
FAU - Ben-Smith, Anne
AU  - Ben-Smith A
FAU - Hoffmann, Wolfgang H
AU  - Hoffmann WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100812
PL  - England
TA  - Int J Parasitol
JT  - International journal for parasitology
JID - 0314024
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - *Brain Diseases
MH  - Cytokines/blood
MH  - Disease Models, Animal
MH  - Female
MH  - Hypothermia/parasitology
MH  - Malaria, Cerebral/*complications/mortality/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Parasitemia
MH  - Plasmodium berghei/*pathogenicity
MH  - Schistosoma mansoni/*pathogenicity
MH  - Schistosomiasis mansoni/*complications/mortality/*pathology
EDAT- 2010/08/17 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/03/16 00:00 [received]
PHST- 2010/06/10 00:00 [revised]
PHST- 2010/06/12 00:00 [accepted]
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S0020-7519(10)00260-2 [pii]
AID - 10.1016/j.ijpara.2010.06.008 [doi]
PST - ppublish
SO  - Int J Parasitol. 2011 Jan;41(1):21-31. doi: 10.1016/j.ijpara.2010.06.008. Epub 
      2010 Aug 12.