PMID- 20708701
OWN - NLM
STAT- MEDLINE
DCOM- 20110518
LR  - 20141120
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Jan
TI  - Exogenous Addition of Minor H Antigen HA-1+ Dendritic Cells to Skin Tissues Ex 
      Vivo Causes Infiltration and Activation of HA-1-Specific Cytotoxic T Cells.
PG  - 69-77
LID - 10.1016/j.bbmt.2010.08.006 [doi]
AB  - T cells specific for hematopoietic system restricted minor Histocompatibility (H) 
      antigens target normal and malignant hematopoietic cells. Thus, cellular immune 
      responses against the latter miHAS eradicate the recipient's hematopoiesis 
      including residual leukemic cells after HLA-matched minor H antigen-mismatched 
      stem-cell transplantation (SCT). However, there are controversial reports on the 
      role of HA-1 in the development of graft-versus-host-disease (GVHD) as well. 
      Here, we address the behavior of HA-1-specific cytotoxic T cells (CTLs) in an ex 
      vivo in situ skin explant model wherein HA-1-expressing dendritic cells (DCs) 
      were added as antigen-presenting cells (APCs). Infiltration and activation of 
      HA-1 CTLs occurred only in those cases where both HLA-A2 and HA-1 were expressed, 
      either by the skin or by the DCs, or by the combination of HLA-A2(+) skin and 
      HA-1(+) DCs. These results point toward the role of recipient's HA-1(+) DCs in 
      the chimeric patient suffering from GVHD after HA-1-mismatched SCT. Although in 
      our model the infiltrated and activated CTLs did not cause skin tissue 
      destruction, our results provide a first step in understanding the reported 
      association of HA-1 mismatching with clinical GVHD.
CI  - 2011. Published by Elsevier Inc.
FAU - Kim, Yeung-Hyen
AU  - Kim YH
AD  - Department of Immunohematology and Blood Transfusion, Leiden University Medical 
      Center, Leiden, The Netherlands.
FAU - Vyth-Dreese, Florry A
AU  - Vyth-Dreese FA
FAU - Schrama, Ellen
AU  - Schrama E
FAU - Pavel, Stan
AU  - Pavel S
FAU - Bajema, Ingeborg
AU  - Bajema I
FAU - Goulmy, Els
AU  - Goulmy E
FAU - Spierings, Eric
AU  - Spierings E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100812
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
RN  - 0 (HA-1 antigen)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (Oligopeptides)
SB  - IM
MH  - Cell Movement
MH  - Dendritic Cells/immunology/*transplantation
MH  - Graft vs Host Disease/*therapy
MH  - Humans
MH  - Immunotherapy/*methods
MH  - In Vitro Techniques
MH  - Lymphocyte Activation
MH  - *Minor Histocompatibility Antigens
MH  - Models, Biological
MH  - *Oligopeptides
MH  - Skin/cytology/immunology
MH  - Skin Diseases/therapy
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 2010/08/17 06:00
MHDA- 2011/05/19 06:00
CRDT- 2010/08/17 06:00
PHST- 2009/12/11 00:00 [received]
PHST- 2010/08/05 00:00 [accepted]
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/05/19 06:00 [medline]
AID - S1083-8791(10)00345-9 [pii]
AID - 10.1016/j.bbmt.2010.08.006 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2011 Jan;17(1):69-77. doi: 
      10.1016/j.bbmt.2010.08.006. Epub 2010 Aug 12.