PMID- 20709118
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20220318
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Linking)
VI  - 154
IP  - 1-2
DP  - 2010 Dec
TI  - Genetic control of host resistance to porcine reproductive and respiratory 
      syndrome virus (PRRSV) infection.
PG  - 161-9
LID - 10.1016/j.virusres.2010.08.004 [doi]
AB  - This manuscript focuses on the advances made using genomic approaches to identify 
      biomarkers that define genes and pathways that are correlated with swine 
      resistance to infection with porcine reproductive and respiratory syndrome virus 
      (PRRSV), the most economically important swine viral pathogen worldwide. 
      International efforts are underway to assess resistance and susceptibility to 
      infectious pathogens using tools such as gene arrays, single nucleotide 
      polymorphisms (SNPs) chips, genome-wide association studies (GWAS), proteomics, 
      and advanced bioinformatics. These studies should identify new candidate genes 
      and biological pathways associated with host PRRS resistance and alternate viral 
      disease processes and mechanisms; they may unveil biomarkers that account for 
      genetic control of PRRS or, alternately, that reveal new targets for therapeutics 
      or vaccines. Previous genomic approaches have expanded our understanding of 
      quantitative trait loci (QTL) controlling traits of economic importance in pig 
      production, e.g., feed efficiency, meat production, leanness; only recently have 
      these included health traits and disease resistance. Genomic studies should have 
      substantial impact for the pig industry since it is now possible to include the 
      use of biomarkers for basic health traits alongside broader set of markers 
      utilized for selection of pigs for improved performance and reproductive traits, 
      as well as pork quality. Additionally these studies may reveal alternate PRRS 
      control mechanisms that can be exploited for novel drugs, biotherapeutics and 
      vaccine designs.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Lunney, Joan K
AU  - Lunney JK
AD  - Animal Parasitic Diseases Laboratory, ANRI, ARS, USDA, BARC-East, Beltsville, MD 
      20705, USA. Joan.Lunney@ars.usda.gov
FAU - Chen, Hongbo
AU  - Chen H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20100813
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
SB  - IM
MH  - Animals
MH  - Genomics/methods
MH  - *Immunity, Innate
MH  - Porcine Reproductive and Respiratory Syndrome/*genetics
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/*pathogenicity
MH  - Proteomics/methods
MH  - Swine
EDAT- 2010/08/17 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2010/08/05 00:00 [accepted]
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - S0168-1702(10)00281-9 [pii]
AID - 10.1016/j.virusres.2010.08.004 [doi]
PST - ppublish
SO  - Virus Res. 2010 Dec;154(1-2):161-9. doi: 10.1016/j.virusres.2010.08.004. Epub 
      2010 Aug 13.