PMID- 20711174
OWN - NLM
STAT- MEDLINE
DCOM- 20100917
LR  - 20221207
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Linking)
VI  - 42
IP  - 9
DP  - 2010 Sep
TI  - Genome-wide association study identifies new HLA class II haplotypes strongly 
      protective against narcolepsy.
PG  - 786-9
LID - 10.1038/ng.647 [doi]
AB  - Narcolepsy is a rare sleep disorder with the strongest human leukocyte antigen 
      (HLA) association ever reported. Since the associated HLA-DRB1*1501-DQB1*0602 
      haplotype is common in the general population (15-25%), it has been suggested 
      that it is almost necessary but not sufficient for developing narcolepsy. To 
      further define the genetic basis of narcolepsy risk, we performed a genome-wide 
      association study (GWAS) in 562 European individuals with narcolepsy (cases) and 
      702 ethnically matched controls, with independent replication in 370 cases and 
      495 controls, all heterozygous for DRB1*1501-DQB1*0602. We found association with 
      a protective variant near HLA-DQA2 (rs2858884; P < 3 x 10(-8)). Further analysis 
      revealed that rs2858884 is strongly linked to DRB1*03-DQB1*02 (P < 4 x 10(-43)) 
      and DRB1*1301-DQB1*0603 (P < 3 x 10(-7)). Cases almost never carried a trans 
      DRB1*1301-DQB1*0603 haplotype (odds ratio = 0.02; P < 6 x 10(-14)). This 
      unexpected protective HLA haplotype suggests a virtually causal involvement of 
      the HLA region in narcolepsy susceptibility.
FAU - Hor, Hyun
AU  - Hor H
AD  - Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
FAU - Kutalik, Zoltan
AU  - Kutalik Z
FAU - Dauvilliers, Yves
AU  - Dauvilliers Y
FAU - Valsesia, Armand
AU  - Valsesia A
FAU - Lammers, Gert J
AU  - Lammers GJ
FAU - Donjacour, Claire E H M
AU  - Donjacour CE
FAU - Iranzo, Alex
AU  - Iranzo A
FAU - Santamaria, Joan
AU  - Santamaria J
FAU - Peraita Adrados, Rosa
AU  - Peraita Adrados R
FAU - Vicario, Jose L
AU  - Vicario JL
FAU - Overeem, Sebastiaan
AU  - Overeem S
FAU - Arnulf, Isabelle
AU  - Arnulf I
FAU - Theodorou, Ioannis
AU  - Theodorou I
FAU - Jennum, Poul
AU  - Jennum P
FAU - Knudsen, Stine
AU  - Knudsen S
FAU - Bassetti, Claudio
AU  - Bassetti C
FAU - Mathis, Johannes
AU  - Mathis J
FAU - Lecendreux, Michel
AU  - Lecendreux M
FAU - Mayer, Geert
AU  - Mayer G
FAU - Geisler, Peter
AU  - Geisler P
FAU - Beneto, Antonio
AU  - Beneto A
FAU - Petit, Brice
AU  - Petit B
FAU - Pfister, Corinne
AU  - Pfister C
FAU - Burki, Julie Vienne
AU  - Burki JV
FAU - Didelot, Gerard
AU  - Didelot G
FAU - Billiard, Michel
AU  - Billiard M
FAU - Ercilla, Guadalupe
AU  - Ercilla G
FAU - Verduijn, Willem
AU  - Verduijn W
FAU - Claas, Frans H J
AU  - Claas FH
FAU - Vollenweider, Peter
AU  - Vollenweider P
FAU - Waeber, Gerard
AU  - Waeber G
FAU - Waterworth, Dawn M
AU  - Waterworth DM
FAU - Mooser, Vincent
AU  - Mooser V
FAU - Heinzer, Raphael
AU  - Heinzer R
FAU - Beckmann, Jacques S
AU  - Beckmann JS
FAU - Bergmann, Sven
AU  - Bergmann S
FAU - Tafti, Mehdi
AU  - Tafti M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100815
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (HLA-D Antigens)
SB  - IM
EIN - Nat Genet. 2011 Apr;43(4):388. Vollenwider, Peter [corrected to Vollenweider, 
      Peter]
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - HLA-D Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Narcolepsy/*genetics
MH  - White People/genetics
EDAT- 2010/08/17 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/04/28 00:00 [received]
PHST- 2010/07/21 00:00 [accepted]
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - ng.647 [pii]
AID - 10.1038/ng.647 [doi]
PST - ppublish
SO  - Nat Genet. 2010 Sep;42(9):786-9. doi: 10.1038/ng.647. Epub 2010 Aug 15.