PMID- 20712124
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Apr
TI  - [Two dimensional capillary zone electrophoresis/micellar electrokinetic capillary 
      chromatography for the analysis of drugs and their enantiomers in urine samples].
PG  - 397-401
AB  - A new two dimensional method, which interfaced capillary zone electrophoresis 
      (CZE) and micellar electrokinetic capillary chromatography (MEKC) by a 
      polytetrafluoroethylene (PTFE) tube with a hole of 30-40 microm diameter on the 
      top, was developed for the analysis of drugs and their enantiomers. The CZE was 
      used as the first dimensional separation, from which the eluting components were 
      transferred and further analyzed by MEKC. Online dual concentration method, pH 
      junction-sweeping, was used to avoid sample zone diffusion at the interface. The 
      separation efficiencies and detection limits were (2.8-4.3) x 10(4)/m and 
      0.015-0.052 mg/L, respectively. The proposed method has successfully demonstrated 
      that in the separation of four drugs and their enantiomers in urine samples, the 
      relative standard deviations (RSDs) of peak area and migration time were in the 
      ranges of 1.7%-3.8% and 1.3%-4.6%, respectively. The method was proved to have 
      good reproducibility, high sensitivity and resolution, large peak capacity. It is 
      reliable and suitable to separate and determine multi-drugs and their enantiomers 
      in urine samples simultaneously.
FAU - Zhang, Xiaowei
AU  - Zhang X
AD  - School of Science, Qingdao Technological University, Qingdao 266033, China. 
      zhangzhx@qust.edu.cn
FAU - Zhang, Zhaoxiang
AU  - Zhang Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 57WA9QZ5WH (Nimodipine)
RN  - 9002-84-0 (Polytetrafluoroethylene)
RN  - 9Y8NXQ24VQ (Propranolol)
SB  - IM
MH  - Chromatography, Micellar Electrokinetic Capillary/*methods
MH  - Electrophoresis, Capillary/*methods
MH  - Nimodipine/chemistry/*urine
MH  - Polytetrafluoroethylene
MH  - Propranolol/chemistry/*urine
MH  - Stereoisomerism
EDAT- 2010/08/18 06:00
MHDA- 2012/01/06 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.3724/sp.j.1123.2010.00397 [doi]
PST - ppublish
SO  - Se Pu. 2010 Apr;28(4):397-401. doi: 10.3724/sp.j.1123.2010.00397.