PMID- 20713602
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20211020
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 190
IP  - 4
DP  - 2010 Aug 23
TI  - Oxidative status of muscle is determined by p107 regulation of PGC-1alpha.
PG  - 651-62
LID - 10.1083/jcb.201005076 [doi]
AB  - Mice lacking p107 exhibit a white adipose deficiency yet do not manifest the 
      metabolic changes typical for lipodystrophy, and instead exhibit low levels of 
      serum triglycerides and a normal liver phenotype. When fed a high fat diet, 
      p107-null mice still did not accumulate fat in the liver, and display markedly 
      elevated energy expenditures together with an increased energy preference for 
      lipids. Skeletal muscle was therefore examined, as this is normally the major 
      tissue involved in whole body lipid metabolism. Notably, p107-deficient muscle 
      express increased levels of peroxisome proliferator-activated receptor gamma 
      co-activator-1alpha (PGC-1alpha) and contained increased numbers of the 
      pro-oxidative type I and type IIa myofibers. Chromatin immunoprecipitation 
      revealed binding of p107 and E2F4 to the PGC-1alpha proximal promoter, and this 
      binding repressed promoter activity in transient transcription assays. Ectopic 
      expression of p107 in muscle tissue in vivo results in a pronounced 20% decrease 
      in the numbers of oxidative type IIa myofibers. Lastly, isolated p107-deficient 
      muscle tissue display a threefold increase in lipid metabolism. Therefore, p107 
      determines the oxidative state of multiple tissues involved in whole body fat 
      metabolism, including skeletal muscle.
FAU - Scime, Anthony
AU  - Scime A
AD  - Regenerative Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, 
      Canada.
FAU - Soleimani, Vahab D
AU  - Soleimani VD
FAU - Bentzinger, C Florian
AU  - Bentzinger CF
FAU - Gillespie, Mark A
AU  - Gillespie MA
FAU - Le Grand, Fabien
AU  - Le Grand F
FAU - Grenier, Guillaume
AU  - Grenier G
FAU - Bevilacqua, Lisa
AU  - Bevilacqua L
FAU - Harper, Mary-Ellen
AU  - Harper ME
FAU - Rudnicki, Michael A
AU  - Rudnicki MA
LA  - eng
GR  - MOP12080/Canadian Institutes of Health Research/Canada
GR  - Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100816
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Dietary Fats)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, mouse)
RN  - 0 (Rbl1 protein, mouse)
RN  - 0 (Retinoblastoma-Like Protein p107)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adipose Tissue, White/cytology/metabolism/physiopathology
MH  - Animals
MH  - Calorimetry
MH  - Diet
MH  - Dietary Fats/metabolism
MH  - Female
MH  - *Lipid Metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Knockout
MH  - Muscle, Skeletal/*metabolism
MH  - *Oxidation-Reduction
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Retinoblastoma-Like Protein p107/genetics/*metabolism
MH  - Trans-Activators/genetics/*metabolism
MH  - Transcription Factors
MH  - Transcription, Genetic
PMC - PMC2928004
EDAT- 2010/08/18 06:00
MHDA- 2010/09/29 06:00
PMCR- 2011/02/23
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
PHST- 2011/02/23 00:00 [pmc-release]
AID - jcb.201005076 [pii]
AID - 201005076 [pii]
AID - 10.1083/jcb.201005076 [doi]
PST - ppublish
SO  - J Cell Biol. 2010 Aug 23;190(4):651-62. doi: 10.1083/jcb.201005076. Epub 2010 Aug 
      16.