PMID- 20714035
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20131121
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 62
IP  - 8
DP  - 2010 Aug
TI  - [Human herpesvirus 6 encephalitis].
PG  - 869-75
AB  - Primary human herpesvirus 6 (HHV-6) infection causes exanthem subitum,a common 
      febrile illness,in infants. At the time of primary infection with HHV-6, the 
      virus rarely causes encephalitis. Recently, various types of clinical features of 
      patients with HHV-6 encephalitis have been reported. Therefore, appropriate 
      procedures for the management of these patients should be established on the 
      basis of the clinical features of the patients. In addition to primary infection 
      with the virus, reactivation of HHV-6 can be associated with encephalitis in the 
      case of immunocompromised patients. Numerous copies of the viral DNA were 
      detected in the cerebrospinal fluid collected from the patients. This finding 
      suggests that active viral replication possibly occurred in the brain tissues of 
      these patients. A typical clinical feature of post transplant HHV-6 encephalitis, 
      was the development of amnesia; further, abnormal magnetic resonance imaging 
      (MRI) findings in the hippocampal regions were observed. Thus, HHV-6 is 
      considered to be one of the causative agents for limbic encephalitis that 
      develops in immunocompromised patients. On the basis of the results of in vitro 
      analysis, it has been suggested that ganciclovir and foscarnet have antiviral 
      effects against HHV-6. Although a double-blind control study has not been 
      performed to elucidate the effectiveness of these 2 drugs in vivo, either of the 
      2 antiviral drugs should be used for the treatment of patients with HHV-6 
      encephalitis.
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
AD  - Department of Pediatrics, Fujita Health University School of Medicine, 
      Kutsukaka-cho, Toyoake, Aichi, Japan.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
RN  - 0 (Antiviral Agents)
RN  - 364P9RVW4X (Foscarnet)
RN  - P9G3CKZ4P5 (Ganciclovir)
SB  - IM
MH  - Antiviral Agents/therapeutic use
MH  - Double-Blind Method
MH  - *Encephalitis, Viral/diagnosis/drug therapy/pathology/virology
MH  - Foscarnet/therapeutic use
MH  - Ganciclovir/therapeutic use
MH  - *Herpesvirus 6, Human/pathogenicity/physiology
MH  - Hippocampus/pathology/virology
MH  - Humans
MH  - Immunocompromised Host
MH  - Infant
MH  - Randomized Controlled Trials as Topic
MH  - *Roseolovirus Infections/drug therapy/pathology/virology
MH  - Virus Replication
EDAT- 2010/08/18 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 1416100736 [pii]
PST - ppublish
SO  - Brain Nerve. 2010 Aug;62(8):869-75.