PMID- 20715508
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20201209
IS  - 0047-1860 (Print)
IS  - 0047-1860 (Linking)
VI  - 58
IP  - 7
DP  - 2010 Jul
TI  - [Results of antifungal susceptibility testing of Candida species and trends of 
      antifungal use in Niigata university medical and dental hospital].
PG  - 658-63
AB  - The accuracy of antifungal susceptibility testing is important for the clinical 
      management of patients with serious infections due to fungus. Our primary 
      objective was to analyze the results of antifungal susceptibility testing of 
      Candida species performed at Niigata University Medical and Dental Hospital and 
      usage of antifungal agents. Antifungal susceptibility testing was performed by 
      the CLSI M27-A2 method. Yeast-like fungi were isolated from 6% of 6,730 samples. 
      All isolates were Candida species, i.e., C. albicans (50%), C. parapsilosis 
      (28%), C. guilliermondii (9%), C. krusei (5%), C. glabrata (4%), and C. 
      tropicalis (4%). The results of the minimum inhibitory concentration that 
      inhibits 90% of the strain tested (MIC90) were 1 microg/mL for fluconazole, 0.5 
      microg/mL for miconazole, 0.06 microg/mL for itoraconazole, < or = 0.03 microg/mL 
      for micafungin, respectively. The results of non-albicans species were 32 
      microg/mL for fluconazole, 8 microg/mL for miconazole, 0.5 microg/mL for 
      itoraconazole, 1 microg/mL for micafungin, respectively. All Candida species were 
      susceptible to the available antifungal agents, except C. krusei that was 
      resistant to fluconazole. Thus, antifungal susceptibility varies greatly 
      according to fungal species. The accuracy of identification of the fungus and 
      antifungal susceptibility would contribute to the proper management of patients 
      with serious fungal infections.
FAU - Aoki, Toshinari
AU  - Aoki T
AD  - Division of Clinical Preventive Medicine, Graduate School of Medical and Dental 
      Sciences, Niigata University, Niigata, Japan. kotobuki-niigata@umin.ac.jp
FAU - Moro, Hiroshi
AU  - Moro H
FAU - Koshio, Nao
AU  - Koshio N
FAU - Tamura, Takashi
AU  - Tamura T
FAU - Tanabe, Yoshinari
AU  - Tanabe Y
FAU - Kawai, Hirokazu
AU  - Kawai H
FAU - Matsuto, Takayuki
AU  - Matsuto T
FAU - Okada, Masahiko
AU  - Okada M
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Rinsho Byori
JT  - Rinsho byori. The Japanese journal of clinical pathology
JID - 2984781R
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Antifungal Agents/administration & dosage/*pharmacology
MH  - Blood/microbiology
MH  - Candida/*drug effects/*isolation & purification
MH  - Drug Resistance, Fungal
MH  - Drug Utilization/*trends
MH  - Female
MH  - Hospitals, University/*statistics & numerical data
MH  - Humans
MH  - Japan
MH  - Male
MH  - Microbial Sensitivity Tests/methods
MH  - Mycoses/diagnosis/*microbiology
MH  - Serologic Tests
EDAT- 2010/08/19 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/08/19 06:00
PHST- 2010/08/19 06:00 [entrez]
PHST- 2010/08/19 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
PST - ppublish
SO  - Rinsho Byori. 2010 Jul;58(7):658-63.