PMID- 20718074
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20131121
IS  - 1860-7187 (Electronic)
IS  - 1860-7179 (Linking)
VI  - 5
IP  - 10
DP  - 2010 Oct 4
TI  - Synthesis of fatty acid amides of catechol metabolites that exhibit antiobesity 
      properties.
PG  - 1781-7
LID - 10.1002/cmdc.201000161 [doi]
AB  - A series of fatty acid amides of 3,4-methylenedioxymethamphetamine (MDMA) 
      catechol metabolites were synthesized in order to evaluate their biological 
      activities. Upon administration, all synthesized compounds resulted in negative 
      modulation of food intake in rats. The most active compounds have affinity for 
      the CB(1) receptor and/or PPAR-alpha; part of their biological activity may be caused 
      by these double interactions.
FAU - Almeida, Bruno
AU  - Almeida B
AD  - Human Pharmacology and Clinical Neurosciences Research Group, IMIM-Hospital del 
      Mar Research Institute, Barcelona 08003, Spain.
FAU - Joglar, Jesus
AU  - Joglar J
FAU - Luque Rojas, Maria Jesus
AU  - Luque Rojas MJ
FAU - Decara, Juan Manuel
AU  - Decara JM
FAU - Bermudez-Silva, Francisco Javier
AU  - Bermudez-Silva FJ
FAU - Macias-Gonzalez, Manuel
AU  - Macias-Gonzalez M
FAU - Fito, Montserrat
AU  - Fito M
FAU - Romero-Cuevas, Miguel
AU  - Romero-Cuevas M
FAU - Farre, Magi
AU  - Farre M
FAU - Covas, Maria Isabel
AU  - Covas MI
FAU - Rodriguez de Fonseca, Fernando
AU  - Rodriguez de Fonseca F
FAU - de la Torre, Rafael
AU  - de la Torre R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - ChemMedChem
JT  - ChemMedChem
JID - 101259013
RN  - 0 (Amides)
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (Catechols)
RN  - 0 (Fatty Acids)
RN  - 0 (PPAR alpha)
RN  - 0 (Receptor, Cannabinoid, CB1)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - LF3AJ089DQ (catechol)
SB  - IM
MH  - Amides/chemical synthesis/*chemistry/pharmacology
MH  - Animals
MH  - Anti-Obesity Agents/*chemical synthesis/chemistry/pharmacology
MH  - Catechols/chemistry/*metabolism
MH  - Fatty Acids/*chemistry
MH  - Kinetics
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/chemistry/metabolism
MH  - PPAR alpha/chemistry/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Cannabinoid, CB1/chemistry/metabolism
EDAT- 2010/08/19 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/08/19 06:00
PHST- 2010/08/19 06:00 [entrez]
PHST- 2010/08/19 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 10.1002/cmdc.201000161 [doi]
PST - ppublish
SO  - ChemMedChem. 2010 Oct 4;5(10):1781-7. doi: 10.1002/cmdc.201000161.