PMID- 20718347
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20221207
IS  - 1003-9279 (Print)
IS  - 1003-9279 (Linking)
VI  - 23
IP  - 6
DP  - 2009 Dec
TI  - [Association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B 
      virus infection].
PG  - 430-3
AB  - OBJECTIVE: To investigate the association between HLA-DQA1 gene polymorphism and 
      the outcomes of hepatitis B virus infection in Chinese Han population. METHODS: A 
      total of 180 consecutive patients with biopsy-proven hepatitis B virus infection 
      (120 patients with chronic hepatitis B and 60 patients with asymptomatic HBV 
      carrier) and 60 subjects who resolved from HBV infection spontaneously were 
      studied. Genotype of human leukocyte antigen(HLA)-DQA1 was detected by polymerase 
      chain reaction sequence specific primer(PCR-SSP). RESULTS: (1) The frequency of 
      HLA-DQA1 * 0201 allele in chronic hepatitis B group was significant higher than 
      the frequency in resolved from HBV infection spontaneously group (38.3% vs. 5.8%, 
      P < 0.001, A = 10.04, 95% CI: 4.48-22.48). The frequency of HLA-DQA1 * 0102 
      allele in chronic hepatitis B group was significant lower than the frequency in 
      resolved from HBV infection spontaneously group (9.6% vs. 36.7%, P < 0.001, A = 
      0.183, 95% CI: 0.10-0.32). (2) The frequency of HLA-DQA1 * 0201 allele in chronic 
      hepatitis B group was significant higher than the frequency in asymptomatic HBV 
      carrier group (38.3% vs. 7.5%, P < 0.01, A = 7.667, 95% CI:3.7-15.87). The 
      frequency of HLA-DQA1 * 0102 allele in chronic hepatitis B group was significant 
      lower than the frequency in asymptomatic HBV carrier group (20% vs. 9.6%, P < 
      0.01, A = 0.424, 95% CI: 0.23-0.79). CONCLUSION: HLA-DQA1 gene polymorphism may 
      play an important role in the outcomes of hepatitis B virus infection in-Chinese 
      Han population. The HLA-DQA1 * 0102 allele could keep individuals away from HBV 
      infection, and HLA-DQA1 * 0201 allele could aggravate persistant infection of HBV 
      and hepatic inflammatory.
FAU - Xun, Yun-hao
AU  - Xun YH
AD  - Hangzhou 6th Hospital, Hangzhou 310014, China.
FAU - Guo, Jian-chun
AU  - Guo JC
FAU - Shi, Wei-zhen
AU  - Shi WZ
FAU - Shi, Jun-ping
AU  - Shi JP
FAU - Liu, Chang-ling
AU  - Liu CL
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
JT  - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang 
      bingduxue zazhi = Chinese journal of experimental and clinical virology
JID - 9602873
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
SB  - IM
MH  - Adult
MH  - Asian People/ethnology/*genetics
MH  - Female
MH  - Genome-Wide Association Study
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - Hepatitis B/ethnology/*genetics/virology
MH  - Hepatitis B virus/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Young Adult
EDAT- 2010/08/20 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
PST - ppublish
SO  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Dec;23(6):430-3.