PMID- 20719174
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20100819
IS  - 1999-6187 (Electronic)
IS  - 1009-3419 (Linking)
VI  - 12
IP  - 8
DP  - 2009 Aug 20
TI  - [Expression and Clinical Significance of ABCC10 in the Patients with Non-small 
      Cell Lung Cancer.].
PG  - 875-8
LID - 10.3779/j.issn.1009-3419.2009.08.08 [doi]
AB  - BACKGROUND: Multidrug resistance (MDR) is the main reason of the failure of 
      chemotherapy in lung cancer. The MDR mechanism in lung cancer is complex, which 
      relates to sorts of drug resistant genes. ABCC10 is a recently identified member 
      of a subset of the C family of ATP-binding cassette (ABC) transporters. The drug 
      resistance capability of ABCC10 has been partly determined. The aim of the study 
      is to investigate the expression of ABCC10 in non small cell lung cancer (NSCLC) 
      and normal tissues, and analyze the relationship between ABCC10 expression level 
      and clinical features, such as TNM stages, histological types and pathological 
      grades. METHODS: The expression of ABCC10 was detected in squamous cell 
      carcinoma, adenocarcinoma and normal lung tissues by immunohistochemistry. Then 
      the statistical analysis was performed. RESULTS: The expression of ABCC10 was 
      mainly located in cell membrane and cytoplasm. There were significant differences 
      between the expression of ABCC10 in NSCLC and normal tissues (P<0.01). The 
      positive rates in squamous cell carcinoma and adenocarcinoma were 73.26% and 
      81.16%, respectively with significant differences (P<0.05). There were 
      significant differences among histological grades in squamous cell carcinoma 
      (P<0.01). There were significant differences among histological grades and TNM 
      stages respectively in adenocarcinoma (P<0.01). CONCLUSIONS: ABCC10 is 
      overexpressed in NSCLC. The expression of ABCC10 in adenocarcinoma is higher than 
      that in squamous cell carcinoma. The expression in adenocarcinoma is correlated 
      to pathological grades and TNM stages. The results of this study would be benefit 
      for further study of ABCC10 in tumor and its chemoresistance.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical 
      University, Xi'an 710038, China.
FAU - Zhang, Zhipei
AU  - Zhang Z
FAU - Gao, Kunxiang
AU  - Gao K
FAU - Deng, Yingchun
AU  - Deng Y
FAU - Zhao, Jinbo
AU  - Zhao J
FAU - Liu, Boya
AU  - Liu B
FAU - Li, Xiaofei
AU  - Li X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2010/08/20 06:00
MHDA- 2010/08/20 06:01
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/08/20 06:01 [medline]
AID - 10.3779/j.issn.1009-3419.2009.08.08 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2009 Aug 20;12(8):875-8. doi: 
      10.3779/j.issn.1009-3419.2009.08.08.