PMID- 20719196
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20100819
IS  - 1999-6187 (Electronic)
IS  - 1009-3419 (Linking)
VI  - 12
IP  - 9
DP  - 2009 Sep 20
TI  - [Expression and its Clinical Significance of NOK, EGFR in NSCLC.].
PG  - 983-8
LID - 10.3779/j.issn.1009-3419.2009.09.008 [doi]
AB  - BACKGROUND: NOK (Novel Oncogene with Kinase-domain) is a newly identified 
      receptor protein-tyrosine kinases (RPTKs) subfamily, which possesses strong 
      oncogenic potential including enhancing cell transformation, tumorigenesis, 
      invasion and metastasis. However, NOK protein lacks extracellular domain, and how 
      the NOK is activated by the membrane receptor and the expression of NOK in non 
      small cell lung cancer (NSCLC) are not clear. Our aim of this study was to 
      investigate the expressions of NOK, EGFR proteins in NSCLC. METHODS: The 
      expression rates of NOK, EGFR proteins in 155 cases with NSCLC was deteced by 
      immunohistochemical stain; The clinical correlations between two proteins were 
      analyzed by statistics. RESULTS: The NOK positive expression was mainly located 
      in cytoplasm and EGFR was mainly located in the plasma membrane and cytoplasm. 
      NOK, EGFR proteins were high expressed in NSCLC and there were extremely 
      differences comparing the expression of NOK, EGFR proteins in squamous cell lung 
      cancer, lung adenocarcinoma with those in corresponding normal tissue 
      respectively (P<0.001); and there were no significant differences between the two 
      kinds of the cancers for their comparison of NOK, EGFR expression (P=0.099; 
      P=0.23); however, there were significant differences for NOK and EGFR expression 
      among histological grades and TNM stages in squamous cell lung cancers, lung 
      adenocarcinoma (P<0.01). There were correlation between positive and intensity of 
      NOK and EGFR expression in whatever total NSCLC or squamous cell lung cancer or 
      lung adenocarcinoma (P<0.001), while the correlation coefficients(rs) were 0742, 
      0.722, 0.756 respectively. CONCLUSIONS: The NOK proteins are highly expressed in 
      the NSCLC, and the expression rates of NOK proteins are correlated with the 
      cancers' histological grades and TNM stages, which may be concern with 
      tumorgenesis and progression; the positive expression rate and intensity of NOK 
      protein correlate well with the expression of EGFR protein in NSCLC, which the 
      activation of NOK probably owe to EGFR activation, all that would provide 
      evidence for further study on the effective mechanism of NOK in the tumorigenesis 
      or tumor progression.
FAU - Zhang, Zhipei
AU  - Zhang Z
AD  - Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical 
      University, Xi'an 710038, China.
FAU - Jiang, Tao
AU  - Jiang T
FAU - Deng, Yingchun
AU  - Deng Y
FAU - Wang, Peng
AU  - Wang P
FAU - Wang, Jian
AU  - Wang J
FAU - Gu, Zhongping
AU  - Gu Z
FAU - Han, Yong
AU  - Han Y
FAU - Wang, Yingyu
AU  - Wang Y
FAU - Zhao, Jinbo
AU  - Zhao J
FAU - Chang, Zhijie
AU  - Chang Z
FAU - Li, Xiaofei
AU  - Li X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2010/08/20 06:00
MHDA- 2010/08/20 06:01
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/08/20 06:01 [medline]
AID - 10.3779/j.issn.1009-3419.2009.09.008 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2009 Sep 20;12(9):983-8. doi: 
      10.3779/j.issn.1009-3419.2009.09.008.