PMID- 20722302
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20100820
IS  - 1745-039X (Print)
IS  - 1477-2817 (Linking)
VI  - 64
IP  - 4
DP  - 2010 Aug
TI  - Protein and energy metabolism of young male Wistar rats fed conjugated linoleic 
      acid as structured triacylglycerol.
PG  - 322-36
LID - 10.1080/1745039X.2010.486594 [doi]
AB  - Twelve 4-week-old male Wistar rats weighing 100 g were fed diets semi-ad libitum 
      for 22 d containing either 1.5% conjugated linoleic acid (CLA-diet) or high oleic 
      sunflower oil (Control-diet). The CLA was structured triacylglycerol with 
      predominantly cis-9, trans-11 and trans-10, cis-12 fatty acid isomers in the 
      inner position and oleic acid in the other positions of the glycerol molecule. 
      The rats were kept individually in metabolic cages. From days 8-16 energy, 
      nitrogen (N) and carbon (C) balances as well as gas exchange measurements in 
      open-air circuit respiration chambers were performed. CLA had no significant 
      influence on feed intake, daily gain in weight or feed conversion efficiency, but 
      the digestibility of nutrients and energy was significantly reduced (except for 
      fat). CLA did not affect N-balance, but reduced the level of daily retained fat 
      (RQ-method: 0.107 vs. 0.417 g/d, p < 0.01) and consequently energy retention in 
      fat. This was explained by increased heat production (HP, RQ-method: 224.6 vs. 
      214.6 kJ/d, p < 0.001) caused by a higher fat oxidation (28.9% vs. 22.3%, p < 
      0.001) at the expense of oxidation of carbohydrates (65.6% vs. 71.4%, p < 0.001), 
      while there was no significant effect on the oxidation of protein (5.5% vs. 
      6.3%). Consequently, the non-protein respiratory quotient (RQnp) was lower in the 
      rats fed the CLA-diet than in the rats fed the Control-diet (0.907 vs. 0.928, p < 
      0.001). Plasma total lipids of the CLA-fed rats had higher concentrations of the 
      cis-9, trans-11 than the trans-10, cis-12 CLA-isomer. This study shows that young 
      male Wistar rats respond to CLA fed as structured triacylglycerol.
FAU - Jorgensen, Henry
AU  - Jorgensen H
AD  - Department of Animal Health and Bioscience, Faculty of Agricultural Sciences, 
      University of Arhus, Tjele, Denmark. henry.jorgensen@agrsci.dk
FAU - Hansen, Christina Horup
AU  - Hansen CH
FAU - Mu, Huiling
AU  - Mu H
FAU - Jakobsen, Kirsten
AU  - Jakobsen K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Arch Anim Nutr
JT  - Archives of animal nutrition
JID - 101222433
RN  - 0 (Linoleic Acids, Conjugated)
RN  - 0 (Proteins)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Animals
MH  - Energy Metabolism/*drug effects
MH  - Linoleic Acids, Conjugated/chemistry/*metabolism
MH  - Male
MH  - Proteins/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Triglycerides/*metabolism
EDAT- 2010/08/21 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1080/1745039X.2010.486594 [doi]
PST - ppublish
SO  - Arch Anim Nutr. 2010 Aug;64(4):322-36. doi: 10.1080/1745039X.2010.486594.