PMID- 20722564
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20161125
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 32
IP  - 8
DP  - 2010
TI  - Protective effect of trapidil and l-arginine against renal and hepatic toxicity 
      induced by cyclosporine in rats.
PG  - 959-68
LID - 10.3109/0886022X.2010.501933 [doi]
AB  - RATIONALE: Cyclosporine A (CsA) leads to renal and liver injury, production of 
      free radicals and nitric oxide (NO) deficiency. This study investigates the 
      possible protective effects of trapidil and L-arginine against CsA-induced tissue 
      injury. OBJECTIVES: Forty adult male Wistar rats (180 +/- 20 g) were divided into 
      five groups, eight animals in each. The first group served as control, second 
      group served as CsA group, third group served as CsA + trapidil group, fourth 
      group served as CsA + L-arginine group, and fifth group served as CsA + trapidil 
      + L-arginine group. Kidney and liver functions, inflammatory mediators, 
      cytokines, oxidant and antioxidant parameters as well as histopathological 
      studies of renal and liver tissue were assessed in all groups. MAIN FINDINGS: CsA 
      induced renal and hepatic dysfunction, which was confirmed by laboratory and 
      histopathological examination. Administration of trapidil diminished the renal 
      and liver injury and significantly attenuated the levels of serum creatinine, 
      urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), 
      interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), monocyte 
      chemoattractant protein-1 (MCP-1), and oxidative stress, while it significantly 
      elevated the level of serum nitric oxide and the activity of antioxidative 
      stress. L-Arginine gave the same trend as trapidil, but trapidil effect was more 
      pronounced. Coadministration of trapidil + L-arginine significantly ameliorated 
      the toxic effect of CsA, but did not differ significantly from the effect of 
      trapidil alone. CONCLUSIONS: Treatment with trapidil or L-arginine diminished the 
      renal and hepatic CsA-induced toxicity. However, the effect of trapidil was more 
      pronounced. Therefore, treatment with trapidil alone may be the most economic and 
      effective as a potential therapeutic agent in CsA injury.
FAU - Salem, Neveen A
AU  - Salem NA
AD  - Medical Division, National Research Centre, Cairo, Egypt.
FAU - Salem, Emad A
AU  - Salem EA
FAU - Maarouf, Aref M
AU  - Maarouf AM
FAU - Kamel, Mostafa
AU  - Kamel M
FAU - Elgalaly, Hazem
AU  - Elgalaly H
FAU - Radwan, Mohamed
AU  - Radwan M
FAU - El-Dayem, Walid A Abd
AU  - El-Dayem WA
FAU - Eladl, Mahmoud
AU  - Eladl M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Vasodilator Agents)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - 94ZLA3W45F (Arginine)
RN  - EYG5Y6355E (Trapidil)
SB  - IM
MH  - Animals
MH  - Arginine/*therapeutic use
MH  - Chemical and Drug Induced Liver Injury/etiology/pathology/*prevention & control
MH  - Cyclosporine/*adverse effects
MH  - Immunosuppressive Agents/adverse effects
MH  - Kidney Diseases/chemically induced/pathology/*prevention & control
MH  - Male
MH  - Nitric Oxide/physiology
MH  - Oxidative Stress/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Trapidil/*therapeutic use
MH  - Vasodilator Agents/*therapeutic use
EDAT- 2010/08/21 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 10.3109/0886022X.2010.501933 [doi]
PST - ppublish
SO  - Ren Fail. 2010;32(8):959-68. doi: 10.3109/0886022X.2010.501933.