PMID- 20722567
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20211020
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 32
IP  - 8
DP  - 2010
TI  - Ang II enhances tubular cell Ets-1 expression and associated down stream 
      signaling is mediated through AT1 receptors.
PG  - 986-91
LID - 10.3109/0886022X.2010.501936 [doi]
AB  - Angiotensin II (Ang II) has been reported to play an important role in both the 
      development and progression of renal injury. Many of the downstream effects of 
      Ang II are mediated through the activation of nuclear factor-kappaB (NF-kappaB). 
      In the present study, we evaluated the effect of Ang II on the activation of 
      Ets-1 (a transcription factor) in tubular cells. In addition, we studied the 
      expression of pro-inflammatory molecules transcribed by Ets-1 in response to Ang 
      II. Mice receiving Ang II infusion showed enhanced renal cortical mRNA expression 
      of Ets-1. Immunolabeling studies localized the expression of Ets-1 in distal 
      tubular cells of mice receiving Ang II. However, this effect of Ang II was 
      mitigated by telmisartan, an AT1-receptor blocker. Mice receiving Ang II infusion 
      also showed increased tubular cell expression of macrophage chemoattractant 
      protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and p21 when 
      compared with control mice; nevertheless, this effect of Ang II was attenuated by 
      telmisartan. In in vitro studies, Ang II enhanced mRNA expression of Ets-1 by 
      MDCK cells. However, this effect of Ang II was inhibited by losartan, an 
      AT1-receptor blocker. Losartan also inhibited Ang II-induced PAI-1 and p21 
      expression by MDCK cells. These findings indicate that Ang II-induced tubular 
      cell expression Ets-1 and associated downstream signaling is mediated through AT1 
      receptors.
FAU - Kumar, Dileep
AU  - Kumar D
AD  - Department of Medicine, North Shore-LIJ Health System, Great Neck, New York 
      11021, USA.
FAU - Luan, Liming
AU  - Luan L
FAU - Pathak, Shresh
AU  - Pathak S
FAU - Salhan, Divya
AU  - Salhan D
FAU - Magoon, Sandeep
AU  - Magoon S
FAU - Singhal, Pravin C
AU  - Singhal PC
LA  - eng
GR  - R01 DK083931/DK/NIDDK NIH HHS/United States
GR  - R01 DK084910/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Proto-Oncogene Protein c-ets-1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0 (Vasoconstrictor Agents)
RN  - 11128-99-7 (Angiotensin II)
SB  - IM
MH  - Angiotensin II/*pharmacology
MH  - Angiotensin Receptor Antagonists/pharmacology
MH  - Animals
MH  - Cell Culture Techniques
MH  - Kidney Tubules, Proximal/*drug effects/metabolism/pathology
MH  - Male
MH  - Mice
MH  - Proto-Oncogene Protein c-ets-1/genetics/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Receptor, Angiotensin, Type 1/*drug effects
MH  - Signal Transduction/*drug effects
MH  - Vasoconstrictor Agents/*pharmacology
EDAT- 2010/08/21 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 10.3109/0886022X.2010.501936 [doi]
PST - ppublish
SO  - Ren Fail. 2010;32(8):986-91. doi: 10.3109/0886022X.2010.501936.