PMID- 20722596
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20101123
LR  - 20100820
IS  - 1746-0921 (Electronic)
IS  - 1746-0913 (Linking)
VI  - 5
IP  - 8
DP  - 2010 Aug
TI  - How do malaria parasites activate dendritic cells?
PG  - 1167-71
LID - 10.2217/fmb.10.85 [doi]
AB  - Evaluation of: Wu X, Gowda NM, Kumar S, Gowda S: Protein-DNA complex is the 
      exclusive malaria parasite component that activates dendritic cells and triggers 
      innate immune responses. J. Immunol. 184(8), 4338-4348 (2010). Malaria parasites 
      induce strong proinflammatory immune responses upon infection. These responses, 
      driven largely by CD4+ Th1 cells, help the body to control malaria parasitemia. 
      When excessive, inflammatory responses contribute to the pathology observed in 
      malaria infection. Dendritic cells (DCs) are innate immune cells that activate 
      Th1 cells in malaria infection via the secretion of the cytokine IL-12. It 
      remains unclear precisely which components of malaria-infected red blood cells 
      are responsible for activating DCs. In this study, Wu et al. set out to 
      deconstruct malaria-infected red blood cells to determine the immunogenic 
      components that induce production of the proinflammatory cytokines IL-12 and 
      TNF-alpha from DCs. The authors suggest that parasite DNA complexed with protein 
      is the main trigger for activation of DCs in malaria-infected red blood cells.
FAU - Lamb, Tracey J
AU  - Lamb TJ
AD  - School of Biological Sciences, Hopkins Building, University of Reading, 
      Whiteknights Campus, Reading RG66UB, UK. t.j.lamb@reading.ac.uk
FAU - Schenk, Michael P
AU  - Schenk MP
FAU - Todryk, Stephen M
AU  - Todryk SM
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Future Microbiol
JT  - Future microbiology
JID - 101278120
CON - J Immunol. 2010 Apr 15;184(8):4338-48. PMID: 20231693
EDAT- 2010/08/21 06:00
MHDA- 2010/08/21 06:01
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2010/08/21 06:01 [medline]
AID - 10.2217/fmb.10.85 [doi]
PST - ppublish
SO  - Future Microbiol. 2010 Aug;5(8):1167-71. doi: 10.2217/fmb.10.85.