PMID- 20723775
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20100820
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 143
IP  - 3
DP  - 2010 Sep
TI  - Immunoglobulin E-mediated food allergies among adults with allergic rhinitis.
PG  - 379-85
LID - 10.1016/j.otohns.2010.04.271 [doi]
AB  - OBJECTIVE: To compare the prevalence of food allergy for peanut, shrimp, and milk 
      in adults with allergic rhinitis and to determine predictive values of these 
      allergens and total immunoglobulin E (IgE) to detect food allergies. STUDY 
      DESIGN: Cross-sectional study. SETTING: University of Chicago Medical Center, 
      Chicago, Illinois. SUBJECTS AND METHODS: We retrospectively analyzed in vitro 
      enzyme-linked immunosorbent assays of adults with rhinitis. Subjects were tested 
      for nine inhalants and three foods (peanut, shrimp, milk) and total IgE. Subjects 
      with food allergy history were tested with additional foods. The sensitivity 
      (SE), specificity (SP), positive predictive value (PPV), and negative predictive 
      value (NPV) of the allergens and total IgE to detect food allergies were 
      calculated. RESULTS: A total of 283 subjects received in vitro tests. Forty-one 
      percent tested negative and 59 percent tested positive for inhalants. The 
      prevalence of subjects with a positive peanut or shrimp allergy in the 
      inhalant-positive population was significantly greater than subjects with milk 
      allergy (23.4% peanut [P = 0.008], 22.2% shrimp [P = 0.001], and 13.2% milk [P = 
      0.008], P = 0.001). For subjects with food allergy history, peanut had the best 
      SP (100.0%), SE (28.1%), PPV (100.0%), and NPV (64.6%) in detecting allergies to 
      other foods. In patients positive for the initial panel (inhalants and peanut), 
      the SP, SE, PPV, and NPV of elevated total IgE was 71.4, 72.4, 77.8, and 65.2 
      percent, respectively. CONCLUSION: Peanut and shrimp were the most common foods 
      encountered in adults with allergic rhinitis. Peanut was best in predicting other 
      food allergies. Total IgE levels with inhalants plus peanut provided the optimal 
      combination of SE, SP, PPV, and NPV. In vitro testing may be important to 
      identify and prevent anaphylaxis to foods in adults.
CI  - Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery 
      Foundation. Published by Mosby, Inc. All rights reserved.
FAU - Sahin-Yilmaz, Asli
AU  - Sahin-Yilmaz A
AD  - Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, 
      University of Chicago, Chicago, IL, USA.
FAU - Nocon, Cheryl C
AU  - Nocon CC
FAU - Corey, Jacquelynne P
AU  - Corey JP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Milk Hypersensitivity/*epidemiology
MH  - Peanut Hypersensitivity/*epidemiology
MH  - *Penaeidae
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Retrospective Studies
MH  - Rhinitis, Allergic, Perennial/blood/*complications/immunology
MH  - Rhinitis, Allergic, Seasonal/blood/*complications/immunology
MH  - Shellfish/adverse effects
MH  - Young Adult
EDAT- 2010/08/21 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/01/21 00:00 [received]
PHST- 2010/04/15 00:00 [revised]
PHST- 2010/04/29 00:00 [accepted]
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0194-5998(10)00687-X [pii]
AID - 10.1016/j.otohns.2010.04.271 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2010 Sep;143(3):379-85. doi: 
      10.1016/j.otohns.2010.04.271.