PMID- 20727009
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20220408
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 18
IP  - 3
DP  - 2011 Mar
TI  - Habituation of evoked responses is greater in patients with familial hemiplegic 
      migraine than in controls: a contrast with the common forms of migraine.
PG  - 478-85
LID - 10.1111/j.1468-1331.2010.03190.x [doi]
AB  - BACKGROUND: Familial hemiplegic migraine (FHM) is a rare, dominantly inherited 
      subtype of migraine with transient hemiplegia during the aura phase. Mutations in 
      at least three different genes can produce the FHM phenotype. The mutated FHM 
      genes code for ion transport proteins that animal and cellular studies have 
      associated with disturbed ion homeostasis, altered cellular excitability, 
      neurotransmitter release, and decreased threshold for cortical spreading 
      depression. The common forms of migraine are characterized interictally by a 
      habituation deficit of cortical and subcortical evoked responses that has been 
      attributed to neuronal dysexcitability. FHM and the common forms of migraine are 
      thought to belong to a spectrum of migraine phenotypes with similar 
      pathophysiology, and we therefore examined whether an abnormal habituation 
      pattern would also be found in FHM patients. METHODS: In a group of genotyped FHM 
      patients (five FHM-1, four FHM-2), we measured habituation of visual evoked 
      potentials (VEP), auditory evoked potentials including intensity dependence 
      (IDAP), the nociception-specific blink reflex (nsBR) and compared the results to 
      a group of healthy volunteers (HV). RESULTS: FHM patients had a more pronounced 
      habituation during VEP (P=0.025) and nsBR recordings (P=0.023) than HV. There was 
      no difference for IDAP, but the slope tended to be steeper in FHM. CONCLUSION: 
      Contrary to the common forms of migraine, FHM patients are not characterized by a 
      deficient, but rather by an increased habituation in cortical/brain stem evoked 
      activities. These results suggest differences between FHM and the common forms of 
      migraine, as far as central neuronal processing is concerned.
CI  - (c) 2010 The Author(s). European Journal of Neurology (c) 2010 EFNS.
FAU - Hansen, J M
AU  - Hansen JM
AD  - Danish Headache Center, Department of Neurology, Glostrup Hospital, Faculty of 
      Health Sciences, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark.
FAU - Bolla, M
AU  - Bolla M
FAU - Magis, D
AU  - Magis D
FAU - de Pasqua, V
AU  - de Pasqua V
FAU - Ashina, M
AU  - Ashina M
FAU - Thomsen, L L
AU  - Thomsen LL
FAU - Olesen, J
AU  - Olesen J
FAU - Schoenen, J
AU  - Schoenen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100818
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
MH  - Adult
MH  - Evoked Potentials/*physiology
MH  - Habituation, Psychophysiologic/*physiology
MH  - Humans
MH  - Middle Aged
MH  - Migraine Disorders/*physiopathology
MH  - Migraine with Aura/genetics/*physiopathology
MH  - Signal Processing, Computer-Assisted
MH  - Young Adult
EDAT- 2010/08/24 06:00
MHDA- 2011/06/01 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - ENE3190 [pii]
AID - 10.1111/j.1468-1331.2010.03190.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2011 Mar;18(3):478-85. doi: 10.1111/j.1468-1331.2010.03190.x. Epub 
      2010 Aug 18.