PMID- 20727514
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20100823
IS  - 1548-5609 (Electronic)
IS  - 1548-5595 (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep
TI  - Incretin-based therapy in chronic kidney disease.
PG  - 439-49
LID - 10.1053/j.ackd.2010.06.003 [doi]
AB  - Type 2 diabetes mellitus (T2DM) with concomitant CKD is an emerging clinical and 
      public health problem reaching epidemic proportions in the United States. 
      Achieving and maintaining glycemic targets in clinical practice are significant 
      challenges in majority of the patients with T2DM and CKD, and this has created 
      significant barriers for clinicians managing these patients. Commonly used 
      antihyperglycemic agents are either contraindicated or lack efficacy and safety 
      information in this population. Recently, 2 distinct classes of agents that 
      augment incretin hormone action have been added to the therapeutic armamentarium 
      targeting hyperglycemia. This review will discuss the literature examining the 
      efficacy and safety of incretin-based therapies in T2DM and the available 
      evidence for their use in CKD.
CI  - 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights 
      reserved.
FAU - Pinelli, Nicole R
AU  - Pinelli NR
AD  - Department of Pharmacy Practice, Wayne State University, Detroit, MI 48201-2427, 
      USA. nickipinelli@wayne.edu
FAU - Moore, Carol L
AU  - Moore CL
FAU - Tomasello, Sarah
AU  - Tomasello S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Chronic Kidney Dis
JT  - Advances in chronic kidney disease
JID - 101209214
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Incretins)
SB  - IM
MH  - *Blood Glucose/drug effects
MH  - Diabetes Mellitus, Type 2/blood/complications/*drug therapy/epidemiology
MH  - Diabetic Nephropathies/blood/epidemiology/etiology/therapy/urine
MH  - Humans
MH  - Hypoglycemic Agents/pharmacology
MH  - *Incretins/pharmacology
MH  - Renal Insufficiency, Chronic/blood/epidemiology/etiology/therapy/urine
MH  - Treatment Outcome
EDAT- 2010/08/24 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/03/06 00:00 [received]
PHST- 2010/05/14 00:00 [revised]
PHST- 2010/06/16 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1548-5595(10)00114-X [pii]
AID - 10.1053/j.ackd.2010.06.003 [doi]
PST - ppublish
SO  - Adv Chronic Kidney Dis. 2010 Sep;17(5):439-49. doi: 10.1053/j.ackd.2010.06.003.