PMID- 2072754
OWN - NLM
STAT- MEDLINE
DCOM- 19910820
LR  - 20190516
IS  - 0025-6196 (Print)
IS  - 0025-6196 (Linking)
VI  - 66
IP  - 7
DP  - 1991 Jul
TI  - Human T-cell lymphotropic virus type I sequences detected by nested polymerase 
      chain reactions are not associated with multiple sclerosis.
PG  - 665-80
AB  - The hypothesis that human T-cell lymphotropic virus type I (HTLV-I) infection is 
      associated with multiple sclerosis (MS) was tested by using primers specific to 
      gag and pol regions of HTLV-I in an analysis that used polymerase chain 
      reactions. No amplification of DNA from patients with MS was detected with 
      primers for either region. After application of a more sensitive scheme with use 
      of nested primers, however, half the samples, including patients with MS and 
      normal control subjects, were found to contain pol DNA sequences. No sequences 
      related to the HTLV-I gag region were detected among patients with MS by using 
      nested primers. Sequences of the amplified HTLV-I pol genomes were determined. 
      Regardless of their origin (MS or normal control), the pol region sequences were 
      similar to HTLV-I sequences reported by other investigators. We conclude that 
      HTLV-I does not have a distinct association with MS, but HTLV-I-related 
      sequences, although in extremely low copy number, may be present in human 
      genomes.
FAU - Prayoonwiwat, N
AU  - Prayoonwiwat N
AD  - Department of Neurology, Mayo Clinic, Rochester, MN 55905.
FAU - Pease, L R
AU  - Pease LR
FAU - Rodriguez, M
AU  - Rodriguez M
LA  - eng
GR  - NS 17750/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - Mayo Clin Proc. 1991 Jul;66(7):752-5. PMID: 2072763
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amino Acid Sequence
MH  - DNA/analysis
MH  - Female
MH  - Genes, gag/genetics
MH  - Genes, pol/genetics
MH  - HTLV-I Infections/genetics
MH  - Human T-lymphotropic virus 1/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Multiple Sclerosis/*genetics/microbiology
MH  - Polymerase Chain Reaction
RF  - 66
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
AID - S0025-6196(12)62078-3 [pii]
AID - 10.1016/s0025-6196(12)62078-3 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 1991 Jul;66(7):665-80. doi: 10.1016/s0025-6196(12)62078-3.