PMID- 20728464
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20161125
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 131
IP  - 9
DP  - 2010 Sep
TI  - Caloric restriction and aging but not overexpression of SOD1 affect hippocampal 
      volumes in mice.
PG  - 574-9
LID - 10.1016/j.mad.2010.08.002 [doi]
AB  - Caloric restriction (CR) and antioxidants have been proposed as strategies to 
      attenuate age-related brain changes. The hippocampus and its subregions dentate 
      gyrus (DG), CA3 and CA1-2 show vulnerability to aging, with hippocampal volume 
      alterations as a measurable sign. Using design-based stereological techniques, we 
      investigated the volumes of the hippocampus and its subregions in six 
      12-month-old and six 24-month-old mice that were randomly selected from four 
      aging cohorts of 60 male mice each: (1) wild-type mice (WT) fed with control diet 
      (CD), (2) transgenic mice oxerexpressing normal human SOD1 fed with CD, (3) WT 
      mice fed with CR diet, and (4) SOD1 mice fed with CR diet. Aging reduced the mean 
      volume of the entire hippocampus (-9.5%), grey (-8.7%) and white matter (-9.7%), 
      and CA3 subregion (-13.6%), but not DG or CA1-2 subregion. CR reduced the mean 
      volumes of every hippocampal region investigated (on average -11%) in both 
      12-month-old, and 24-month-old mice. Overexpression of SOD1 was not associated 
      with any volume alteration. These findings indicate that although aging and CR in 
      mice are both associated with hippocampal volume reductions, the patterns of the 
      volume reductions differ. These morphometric alterations may have impact on the 
      function of the hippocampus during aging and CR.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Rutten, Bart P F
AU  - Rutten BP
AD  - Department of Psychiatry & Neuropsychology, School for Mental Health and 
      Neurosciences, Maastricht University, NL-6200 MD Maastricht, The Netherlands. 
      b.rutten@np.unimaas.nl
FAU - Brasnjevic, Ivona
AU  - Brasnjevic I
FAU - Steinbusch, Harry W M
AU  - Steinbusch HW
FAU - Schmitz, Christoph
AU  - Schmitz C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100820
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (SOD1 protein, human)
RN  - EC 1.15.1.1 (Sod1 protein, mouse)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.15.1.1 (Superoxide Dismutase-1)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Brain/metabolism
MH  - Brain Mapping
MH  - Caloric Restriction/*methods
MH  - DNA Damage
MH  - Dentate Gyrus/physiology
MH  - Female
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Mice
MH  - Models, Neurological
MH  - Superoxide Dismutase/*genetics/*physiology
MH  - Superoxide Dismutase-1
MH  - Time Factors
EDAT- 2010/08/24 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/08/24 06:00
PHST- 2009/11/12 00:00 [received]
PHST- 2010/08/09 00:00 [revised]
PHST- 2010/08/12 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - S0047-6374(10)00151-X [pii]
AID - 10.1016/j.mad.2010.08.002 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2010 Sep;131(9):574-9. doi: 10.1016/j.mad.2010.08.002. Epub 2010 
      Aug 20.