PMID- 20728785
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20100823
IS  - 0210-5705 (Print)
IS  - 0210-5705 (Linking)
VI  - 33 Suppl 1
DP  - 2010 May
TI  - [Safety and interactions of proton pump inhibitors: lessons learned in millions 
      of patients].
PG  - 15-21
LID - 10.1016/S0210-5705(10)70004-2 [doi]
AB  - After many years of widespread use, proton pump inhibitors (PPI) have been 
      demonstrated to be relatively safe. The most frequently associated adverse 
      reactions are mild with scarce clinical effects. These agents produce 
      hypergastrinemia but this adverse effect has not been related to the development 
      of malignancies. PPI seem to facilitate certain bacterial infections in the 
      gastrointestinal and respiratory tracts. However, these infections are easily 
      treated and therefore do not limit the prescription of PPI. From the 
      pharmacokinetic point of view, the possibility of interactions with other drugs 
      metabolized by the cytochrome P450 system has been described but these 
      interactions generally seem to have little clinical or therapeutic importance. 
      However, regulatory agencies are currently stressing the hypothetical interaction 
      between PPI (especially omeprazole) and clopidogrel, which reduces the latter's 
      antiplatelet effect. Although this recommendation should be followed, this 
      interaction should be specifically evaluated to determine its clinical effect and 
      the possible alternatives in patients at risk of gastrointestinal bleeding. 
      Lastly, the present article reviews PPI administration in special, currently 
      debated situations, such as in pregnant or breastfeeding women.
CI  - Copyright (c) 2010 Elsevier Espana S.L. All rights reserved.
FAU - Esplugues, Juan V
AU  - Esplugues JV
AD  - Departamento de Farmacologia, Facultad de Medicina, Universidad de Valencia, 
      Valencia, Espana. juan.v.esplugues@uv.es
FAU - Marti-Cabrera, Miguel
AU  - Marti-Cabrera M
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Seguridad e interacciones de los inhibidores de la bomba de protones: lecciones 
      aprendidas en millones de pacientes.
PL  - Spain
TA  - Gastroenterol Hepatol
JT  - Gastroenterologia y hepatologia
JID - 8406671
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Drug Interactions
MH  - Humans
MH  - Proton Pump Inhibitors/pharmacokinetics/*pharmacology/toxicity
MH  - Safety
EDAT- 2010/09/03 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - S0210-5705(10)70004-2 [pii]
AID - 10.1016/S0210-5705(10)70004-2 [doi]
PST - ppublish
SO  - Gastroenterol Hepatol. 2010 May;33 Suppl 1:15-21. doi: 
      10.1016/S0210-5705(10)70004-2.