PMID- 20730634
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20211020
IS  - 1473-4230 (Electronic)
IS  - 1473-4222 (Linking)
VI  - 9
IP  - 4
DP  - 2010 Dec
TI  - Inferior olive response to passive tactile and visual stimulation with variable 
      interstimulus intervals.
PG  - 598-602
LID - 10.1007/s12311-010-0203-8 [doi]
AB  - The unique anatomical and electrophysiological features of the inferior olive and 
      its importance to cerebellar function have been recognized for decades. However, 
      understanding the exact function of the inferior olive has been limited by the 
      general lack of correlation between its neural activity and specific behavioral 
      states. Electrophysiological studies in animals showed that the inferior olive 
      response to sensory stimuli is generally invariant to stimulus properties but is 
      enhanced by unexpected stimuli. Using functional magnetic resonance imaging in 
      humans, we have shown that the inferior olive is activated when subjects 
      performed a task requiring perception of visual stimuli with unpredictable timing 
      (Xu et al. J Neurosci 26(22):5990-5995, 2006, Liu et al. J Neurophysiol 
      100(3):1557-1561, 2008). In the current study, subjects were scanned while 
      passively perceiving visual and tactile stimuli that were rendered unpredictable 
      by continuously varying interstimulus intervals (ISIs). Sequences of visual 
      stimuli and tactile stimuli to the right hand were presented separately within 
      the same scanning session. In addition to the activation of multiple areas in the 
      cerebellar cortex consistent with previous imaging studies, the results show that 
      both tactile and visual stimulation with variable ISIs were effective in 
      activating the inferior olive. Together with our previous findings, the current 
      results are consistent with the electrophysiological studies in animals and 
      further support the view that the inferior olive and the climbing fiber system 
      primarily convey the temporal information of sensory input regardless of the 
      modality.
FAU - Wu, X
AU  - Wu X
AD  - Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
FAU - Nestrasil, I
AU  - Nestrasil I
FAU - Ashe, J
AU  - Ashe J
FAU - Tuite, P
AU  - Tuite P
FAU - Bushara, K
AU  - Bushara K
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Cerebellum
JT  - Cerebellum (London, England)
JID - 101089443
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Afferent Pathways/blood supply
MH  - Brain Mapping
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Olivary Nucleus/*anatomy & histology/blood supply/*physiology
MH  - Oxygen/blood
MH  - Photic Stimulation/*methods
MH  - Time Factors
MH  - Touch/*physiology
EDAT- 2010/08/24 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - 10.1007/s12311-010-0203-8 [doi]
PST - ppublish
SO  - Cerebellum. 2010 Dec;9(4):598-602. doi: 10.1007/s12311-010-0203-8.