PMID- 20730798
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20211020
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 65
IP  - 5
DP  - 2011 May
TI  - Comparison of (+)-methamphetamine, +/--methylenedioxymethamphetamine, 
      (+)-amphetamine and +/--fenfluramine in rats on egocentric learning in the 
      Cincinnati water maze.
PG  - 368-78
LID - 10.1002/syn.20854 [doi]
AB  - (+)-Methamphetamine (MA), (+/-)-3,4-methylenedioxymethamphetamine (MDMA), 
      (+)-amphetamine (AMPH), and (+/-)-fenfluramine (FEN) are phenylethylamines with CNS 
      effects. At higher doses, each induces protracted reductions in brain dopamine 
      (DA) and/or serotonin. Chronic MA and MDMA users show persistent monoamine 
      reductions and cognitive impairments. In rats, similar neurochemical effects can 
      be induced, yet cognitive impairments have been difficult to demonstrate. We 
      recently showed that rats treated on a single day with MA (10 mg/kg x 4 at 2 h 
      intervals) exhibit impaired egocentric learning (Cincinnati water maze [CWM]) 
      without affecting spatial learning (Morris water maze [MWM]) (Herring et al., 
      [2008] Psychopharmacology (Berl) 199:637-650). Whether this effect is unique to 
      MA or is a general characteristic of these drugs is unknown. Accordingly, this 
      experiment compared these drugs on CWM performance. Drugs were given s.c. in four 
      doses at 2 h intervals. MA doses were 10 or 12.5 mg/kg/dose, AMPH 25 mg/kg/dose 
      (to match MA12.5-induced hyperthermia), MDMA 15 mg/kg/dose (previously 
      established hyperthermia-inducing dose), and FEN 16.5 mg/kg/dose (equimolar to 
      MA12.5). Two weeks later, rats were tested in the CWM (2 trials/day, 21 days). 
      AMPH and MA (both doses) induced significant increases in CWM errors and latency 
      to reach the goal with no differences in swim speed. MDMA and FEN did not 
      significantly alter learning. Given that FEN selectively and MDMA preferentially 
      affect serotonin whereas AMPH selectively and MA preferentially affect DA, the 
      data suggest that egocentric learning may be predominantly dopaminergically 
      mediated.
FAU - Vorhees, Charles V
AU  - Vorhees CV
AD  - Division of Neurology, Department of Pediatrics, Cincinnati Children's Research 
      Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 
      45229, USA. charles.vorhees@cchmc.org
FAU - He, Elizabeth
AU  - He E
FAU - Skelton, Matthew R
AU  - Skelton MR
FAU - Graham, Devon L
AU  - Graham DL
FAU - Schaefer, Tori L
AU  - Schaefer TL
FAU - Grace, Curtis E
AU  - Grace CE
FAU - Braun, Amanda A
AU  - Braun AA
FAU - Amos-Kroohs, Robyn
AU  - Amos-Kroohs R
FAU - Williams, Michael T
AU  - Williams MT
LA  - eng
GR  - R01 DA006733/DA/NIDA NIH HHS/United States
GR  - R01 DA006733-17/DA/NIDA NIH HHS/United States
GR  - T35 DK060444/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
DEP - 20101008
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Serotonin Agents)
RN  - 2DS058H2CF (Fenfluramine)
RN  - 44RAL3456C (Methamphetamine)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine/pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Body Temperature/drug effects
MH  - Body Weight/drug effects
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cold Temperature
MH  - Fenfluramine/pharmacology
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Methamphetamine/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin Agents/*pharmacology
MH  - Spatial Behavior/*drug effects
MH  - Swimming
MH  - Time Factors
PMC - PMC2994999
MID - NIHMS230118
EDAT- 2010/08/24 06:00
MHDA- 2011/06/24 06:00
PMCR- 2012/05/01
CRDT- 2010/08/24 06:00
PHST- 2009/12/31 00:00 [received]
PHST- 2010/07/09 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - 10.1002/syn.20854 [doi]
PST - ppublish
SO  - Synapse. 2011 May;65(5):368-78. doi: 10.1002/syn.20854. Epub 2010 Oct 8.