PMID- 2073086
OWN - NLM
STAT- MEDLINE
DCOM- 19910410
LR  - 20081121
IS  - 0091-7370 (Print)
IS  - 0091-7370 (Linking)
VI  - 20
IP  - 6
DP  - 1990 Nov-Dec
TI  - Anti-thymocyte globulin induced thrombocytopenia.
PG  - 373-8
AB  - Anti-thymocyte globulin is strongly reactive with platelets as measured by flow 
      cytometric analysis. This reactivity appears to be independent of human leukocyte 
      antigen (HLA) phenotype, is dose-dependent with saturation of platelet binding 
      sites readily achieved with concentrations of horse anti-thymocyte globulin (ATG) 
      at 0.25 mg per ml, and cannot be blocked with human anti-PLA1 antibody nor with 
      heat-aggregated human IgG. Results of immunoblot studies after electrophoresis of 
      platelet membrane proteins are consistent with the proposal that horse ATG 
      contains antibodies specific for platelet glycoproteins V and IIa.
FAU - Lazarchick, J
AU  - Lazarchick J
AD  - Department of Pathology/Laboratory Medicine, Medical University of South 
      Carolina, Charleston 29425.
FAU - Russell, R
AU  - Russell R
FAU - Horn, B
AU  - Horn B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (HLA Antigens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Isoantibodies)
RN  - 0 (Platelet Membrane Glycoproteins)
RN  - 0 (Receptors, Fc)
RN  - 0 (anti-Thy antibody)
SB  - IM
MH  - Antibody Specificity
MH  - Blood Platelets/immunology
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Flow Cytometry
MH  - HLA Antigens/immunology
MH  - Hot Temperature
MH  - Humans
MH  - Immunoblotting
MH  - Immunoglobulin G/immunology
MH  - Isoantibodies/*adverse effects/immunology
MH  - Molecular Weight
MH  - Platelet Membrane Glycoproteins/immunology
MH  - Receptors, Fc/immunology
MH  - Thrombocytopenia/*etiology
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
PST - ppublish
SO  - Ann Clin Lab Sci. 1990 Nov-Dec;20(6):373-8.