PMID- 20731103
OWN - NLM
STAT- MEDLINE
DCOM- 20101221
LR  - 20100824
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 82
IP  - 6
DP  - 2010
TI  - [Renal artery stenosis in patients with type 2 diabetes mellitus: clinical signs, 
      diagnosis, prognostic value].
PG  - 15-21
AB  - AIM: To define the prevalence, clinical features, risk factors, and prognostic 
      value of atherosclerotic renal artery stenosis (RAS) in patients with type 2 
      diabetes mellitus (T2DM). SUBJECTS AND METHODS: One hundred and fifty-seven T2DM 
      patients (63 males and 94 females) aged over 50 years were examined. Screening 
      for RAS was carried out by duplex ultrasound scanning (DUSS); the diagnosis was 
      verified by multispiral computed tomography and magnetic resonance imaging. 
      Moreover, the detection rate of RAS was analyzed from the selective angiographic 
      readings of 30 patients with T2DM and 26 coronary angiography patients without DM 
      who had undergone coronary angiography (CA). RESULTS: In the total group of T2DM 
      patients, the RAS detection rate was 36.9%, as evidenced by DUSS and 43.3% by 
      selective renal artery angiography in the patients who had undergone CA. The 
      factors associated with the development of RAS were smoking (relative risk (RR) = 
      3.3; p < 0.001); atherosclerosis of coronary (RR = 4.28; p < 0.001) and 
      peripheral (RR = 3.38; p < 0.02) arteries, isolated systolic hypertension (RR = 
      3.9; p < 0.01), and anemia (RR = 6.4; p < 0.001). In patients with T2DM, RAS was 
      one of the important factors of progressive renal and cardiac diseases and 
      increased mortality determined by the combined end point: death, emergency 
      hospitalization for heart failure, myocardial infarction, double creatinine, and 
      end-stage renal failure (RR = 6.28; p < 0.001). CONCLUSION: The optimization of 
      prognosis in T2DM patients with RAS requires its timely clinical identification 
      in combination with other types of renal lesion, aggressive correction of the 
      mechanisms of the progressive process, and development of medical and 
      endovascular therapies.
FAU - Shamkhalova, M Sh
AU  - Shamkhalova MSh
FAU - Klefortova, I I
AU  - Klefortova II
FAU - Shestakova, M V
AU  - Shestakova MV
FAU - Remizov, O V
AU  - Remizov OV
FAU - Bukhman, A I
AU  - Bukhman AI
FAU - Alpenidze, V A
AU  - Alpenidze VA
FAU - Tugeeva, E F
AU  - Tugeeva EF
FAU - Shariia, M A
AU  - Shariia MA
FAU - Ustiuzhanin, D V
AU  - Ustiuzhanin DV
FAU - Buziashvili, Iu I
AU  - Buziashvili IuI
FAU - Dedov, I I
AU  - Dedov II
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
SB  - IM
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Kidney Function Tests
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - *Renal Artery Obstruction/diagnosis/epidemiology/etiology
MH  - Survival Analysis
MH  - Tomography, Spiral Computed
EDAT- 2010/08/25 06:00
MHDA- 2010/12/22 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2010/12/22 06:00 [medline]
PST - ppublish
SO  - Ter Arkh. 2010;82(6):15-21.