PMID- 20732366
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20131121
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 11
DP  - 2010 Nov
TI  - Tumor necrosis factor-alpha, transforming growth factor-beta1, and interleukin-10 
      gene polymorphisms: implication in protection or susceptibility to dengue 
      hemorrhagic fever.
PG  - 1135-40
LID - 10.1016/j.humimm.2010.08.004 [doi]
AB  - Dengue virus infection has emerged as one of the most important arthropod-borne 
      viral diseases. Some dengue infected individuals develop the severe, 
      life-threatening form of the disease, dengue hemorrhagic fever/dengue shock 
      syndrome (DHF/DSS). Host genetic factors may be relevant and may predispose some 
      individuals to the severe illness. Human leukocyte antigen (HLA), FcgammaR, tumor 
      necrosis factor (TNF)-alpha, and dendritic cell-specific intracellular adhesion 
      molecule-3-grabbing nonintegrin (DC-SIGN), among others genes have been 
      associated with the pathogenesis of dengue. Little is known, however, about the 
      predictive value of cytokine genotypes for the clinical outcome of dengue 
      infection. In this study, the TNF-alpha, interleukin (IL)-6, interferon (IFN)-gamma, 
      IL-10 and transforming growth factor (TGF)-beta1 gene single nucleotide 
      polymorphisms (SNP) were studied by polymerase chain reaction-sequence-specific 
      primer in a group of individuals with the antecedent of DHF during a secondary 
      infection in the sequence dengue 1/dengue 2. A control group was also included. 
      TNF-alpha (-308) A allele and IL-10 (-1082/-819/-592) ACC/ATA haplotype were 
      significantly associated with DHF. TNF-alpha (-308) GG and TGF-beta1 (c25) GG genotypes 
      were associated with protection. Our results suggest that genetic predisposition 
      to a high TNF-alpha production and a low IL-10 production seems to increase the 
      susceptibility to DHF during a secondary dengue 2 infection, whereas TGF-beta1 high 
      producers might be protected for developing DHF.
CI  - Copyright (c) 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Perez, Ana B
AU  - Perez AB
AD  - PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Institute 
      for Tropical Medicine Pedro Kouri, Havana, Cuba. anab@ipk.sld.cu
FAU - Sierra, Beatriz
AU  - Sierra B
FAU - Garcia, Gissel
AU  - Garcia G
FAU - Aguirre, Eglis
AU  - Aguirre E
FAU - Babel, Nina
AU  - Babel N
FAU - Alvarez, Mayling
AU  - Alvarez M
FAU - Sanchez, Licel
AU  - Sanchez L
FAU - Valdes, Luis
AU  - Valdes L
FAU - Volk, Hans D
AU  - Volk HD
FAU - Guzman, Maria G
AU  - Guzman MG
LA  - eng
PT  - Journal Article
DEP - 20100821
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Dengue Virus/*immunology/pathogenicity
MH  - Disease Progression
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-10/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Predictive Value of Tests
MH  - Severe Dengue/genetics/*immunology/physiopathology
MH  - Shock
MH  - Transforming Growth Factor beta1/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2010/08/25 06:00
MHDA- 2011/05/06 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/02/11 00:00 [received]
PHST- 2010/07/18 00:00 [revised]
PHST- 2010/08/16 00:00 [accepted]
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - S0198-8859(10)00472-6 [pii]
AID - 10.1016/j.humimm.2010.08.004 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Nov;71(11):1135-40. doi: 10.1016/j.humimm.2010.08.004. Epub 
      2010 Aug 21.