PMID- 20735230
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20100825
IS  - 1748-6963 (Electronic)
IS  - 1743-5889 (Linking)
VI  - 5
IP  - 6
DP  - 2010 Aug
TI  - Carbon nanotube ecotoxicity in amphibians: assessment of multiwalled carbon 
      nanotubes and comparison with double-walled carbon nanotubes.
PG  - 963-74
LID - 10.2217/nnm.10.60 [doi]
AB  - The potential impact of industrial multiwalled carbon nanotubes (MWNTs) was 
      investigated under normalized laboratory conditions according to the 
      International Standard micronucleus assay ISO 21427-1 for 12 days of half-static 
      exposure to 0.1, 1, 10 and 50 mg/l of MWNTs in water. Three different end points 
      were carried out for 12 days of exposure: mortality, growth inhibition and 
      micronuclei induction in erythrocytes of the circulating blood of larvae. Raman 
      spectroscopy analysis was used to study the presence of carbon nanotubes in the 
      biological samples. Considering the high diversity of carbon nanotubes according 
      to their different characteristics, MWNTs were analyzed in Xenopus larvae, 
      comparatively to double-walled carbon nanotubes used in a previous study in 
      similar conditions. Growth inhibition in larvae exposed to 50 mg/l of MWNTs was 
      evidenced; however, no genetoxicity (micronucleus assay) was noticed, at any 
      concentration. Carbon nanotube localization in the larvae leads to different 
      possible hypothesis of mechanisms explaining toxicity in Xenopus.
FAU - Mouchet, Florence
AU  - Mouchet F
AD  - Laboratoire d'Ecologie Fonctionnelle, ENSAT, Universite de Toulouse, UPS, INP, 
      F-31326 Castanet-Tolosan, France. florence.mouchet@orange.fr
FAU - Landois, Perine
AU  - Landois P
FAU - Puech, Pascal
AU  - Puech P
FAU - Pinelli, Eric
AU  - Pinelli E
FAU - Flahaut, Emmanuel
AU  - Flahaut E
FAU - Gauthier, Laury
AU  - Gauthier L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Nanomedicine (Lond)
JT  - Nanomedicine (London, England)
JID - 101278111
RN  - 0 (Nanotubes, Carbon)
SB  - IM
MH  - Amphibians/*physiology
MH  - Animals
MH  - *Nanotubes, Carbon
EDAT- 2010/08/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.2217/nnm.10.60 [doi]
PST - ppublish
SO  - Nanomedicine (Lond). 2010 Aug;5(6):963-74. doi: 10.2217/nnm.10.60.