PMID- 2073588
OWN - NLM
STAT- MEDLINE
DCOM- 19910418
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 534
IP  - 1-2
DP  - 1990 Nov 26
TI  - Effect of ibotenic acid lesions of the medial prefrontal cortex on 
      amphetamine-induced locomotion and regional brain catecholamine concentrations in 
      the rat.
PG  - 263-72
AB  - To determine the influence of intrinsic medial prefrontal cortex (MPFC) neurons 
      on regional brain catecholamine turnover, dopamine (DA) and its metabolites were 
      assayed in several brain areas 14 and 28 days after bilateral ibotenic acid (IA) 
      lesions of the MPFC in the rat. The locomotor response to D-amphetamine was also 
      assessed. On the 14th postoperative day levels of DA, homovanillic acid 
      concentrations and 3,4-dihydroxyphenylacetic acid were elevated in the anterior 
      striatum of IA-lesioned animals. Spontaneous and amphetamine-induced locomotion 
      were also increased. These changes disappeared by the 28th postoperative day. It 
      is concluded that destruction of the efferents of the MPFC induces transient 
      increases in DA turnover within the medial striatum and transiently increases 
      spontaneous and amphetamine-induced locomotion.
FAU - Jaskiw, G E
AU  - Jaskiw GE
AD  - Clinical Brain Disorders Branch, National Institutes of Mental Health, St. 
      Elizabeths Hospital, Washington, DC 20032.
FAU - Karoum, F
AU  - Karoum F
FAU - Freed, W J
AU  - Freed WJ
FAU - Phillips, I
AU  - Phillips I
FAU - Kleinman, J E
AU  - Kleinman JE
FAU - Weinberger, D R
AU  - Weinberger DR
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Catecholamines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 2552-55-8 (Ibotenic Acid)
RN  - TZ47U051FI (Dextroamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Catecholamines/metabolism
MH  - Cerebral Cortex/drug effects/pathology/*physiology
MH  - Dextroamphetamine/*pharmacology
MH  - Dopamine/metabolism
MH  - Habituation, Psychophysiologic
MH  - Homovanillic Acid/metabolism
MH  - Ibotenic Acid/*toxicity
MH  - Locomotion/*drug effects
MH  - Male
MH  - Norepinephrine/metabolism
MH  - Organ Specificity
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
EDAT- 1990/11/26 00:00
MHDA- 1990/11/26 00:01
CRDT- 1990/11/26 00:00
PHST- 1990/11/26 00:00 [pubmed]
PHST- 1990/11/26 00:01 [medline]
PHST- 1990/11/26 00:00 [entrez]
AID - 0006-8993(90)90138-2 [pii]
AID - 10.1016/0006-8993(90)90138-2 [doi]
PST - ppublish
SO  - Brain Res. 1990 Nov 26;534(1-2):263-72. doi: 10.1016/0006-8993(90)90138-2.