PMID- 20735886
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20211020
IS  - 1469-7661 (Electronic)
IS  - 1355-6177 (Print)
IS  - 1355-6177 (Linking)
VI  - 16
IP  - 6
DP  - 2010 Nov
TI  - Preliminary evidence of motor impairment among polysubstance 
      3,4-methylenedioxymethamphetamine users with intact neuropsychological 
      functioning.
PG  - 1047-55
LID - 10.1017/S1355617710000846 [doi]
AB  - Neuropsychological disturbances have been reported in association with use of the 
      recreational drug "ecstasy," or 3,4-methylenedioxymethamphetamine (MDMA), but 
      findings have been inconsistent. We performed comprehensive neuropsychological 
      testing examining seven ability domains in 21 MDMA users (MDMA+) and 21 matched 
      control participants (MDMA-). Among MDMA+ participants, median [interquartile 
      range] lifetime MDMA use was 186 [111, 516] doses, with 120 [35-365] days of 
      abstinence. There were no significant group differences in neuropsychological 
      performance, with the exception of the motor speed/dexterity domain in which 43% 
      of MDMA+ were impaired compared with 5% of MDMA- participants (p = .004). Motor 
      impairment differences were not explained by use of other substances and were 
      unrelated to length of abstinence or lifetime number of MDMA doses. Findings 
      provide limited evidence for neuropsychological differences between MDMA+ and 
      MDMA- participants with the exception of motor impairments observed in the MDMA+ 
      group. However, replication of this finding in a larger sample is warranted.
FAU - Bousman, Chad A
AU  - Bousman CA
AD  - Department of Psychiatry, University of California San Diego, La Jolla, 
      California 92093, USA.
FAU - Cherner, Mariana
AU  - Cherner M
FAU - Emory, Kristen T
AU  - Emory KT
FAU - Barron, Daniel
AU  - Barron D
FAU - Grebenstein, Patricia
AU  - Grebenstein P
FAU - Atkinson, J Hampton
AU  - Atkinson JH
FAU - Heaton, Robert K
AU  - Heaton RK
FAU - Grant, Igor
AU  - Grant I
CN  - HNRC Group
LA  - eng
GR  - R03 MH064903/MH/NIMH NIH HHS/United States
GR  - P30 MH062512/MH/NIMH NIH HHS/United States
GR  - P01 DA012065/DA/NIDA NIH HHS/United States
GR  - P01-DA12065/DA/NIDA NIH HHS/United States
GR  - P30-MH62512/MH/NIMH NIH HHS/United States
GR  - R03-MH64903/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100825
PL  - England
TA  - J Int Neuropsychol Soc
JT  - Journal of the International Neuropsychological Society : JINS
JID - 9503760
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Amphetamine-Related Disorders/*complications/epidemiology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Movement Disorders/epidemiology/*etiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - *Neuropsychological Tests
MH  - Substance Withdrawal Syndrome/complications
MH  - Young Adult
PMC - PMC3737074
MID - NIHMS492007
FIR - Grant, Igor
IR  - Grant I
FIR - Hampton Atkinson, J
IR  - Hampton Atkinson J
FIR - Ellis, Ronald J
IR  - Ellis RJ
FIR - McCutchan, J Allen
IR  - McCutchan JA
FIR - Marcotte, Thomas D
IR  - Marcotte TD
FIR - Sherman, Melanie
IR  - Sherman M
FIR - Hale, Braden R
IR  - Hale BR
FIR - Letendre, Scott
IR  - Letendre S
FIR - Capparelli, Edmund
IR  - Capparelli E
FIR - Schrier, Rachel
IR  - Schrier R
FIR - Marquie-Beck, Jennifer
IR  - Marquie-Beck J
FIR - Alexander, Terry
IR  - Alexander T
FIR - Heaton, Robert K
IR  - Heaton RK
FIR - Cherner, Mariana
IR  - Cherner M
FIR - Woods, Steven Paul
IR  - Woods SP
FIR - Moore, David J
IR  - Moore DJ
FIR - Dawson, Matthew
IR  - Dawson M
FIR - Franklin, Donald
IR  - Franklin D
FIR - Jernigan, Terry
IR  - Jernigan T
FIR - Fennema-Notestine, Christine
IR  - Fennema-Notestine C
FIR - Archibald, Sarah L
IR  - Archibald SL
FIR - Hesselink, John
IR  - Hesselink J
FIR - Annese, Jacopo
IR  - Annese J
FIR - Taylor, Michael J
IR  - Taylor MJ
FIR - Masliah, Eliezer
IR  - Masliah E
FIR - Everall, Ian
IR  - Everall I
FIR - Achim, Cristian
IR  - Achim C
FIR - Richman, Douglas
IR  - Richman D
FIR - Smith, David M
IR  - Smith DM
FIR - Everall, Ian
IR  - Everall I
FIR - Lipton, Stuart
IR  - Lipton S
FIR - von Jaeger, Rodney
IR  - von Jaeger R
FIR - Gamst, Anthony C
IR  - Gamst AC
FIR - Masys, Daniel R
IR  - Masys DR
FIR - Abramson, Ian
IR  - Abramson I
FIR - Vaida, Florin
IR  - Vaida F
FIR - Ake, Christopher
IR  - Ake C
EDAT- 2010/08/26 06:00
MHDA- 2011/04/06 06:00
PMCR- 2013/08/07
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
PHST- 2013/08/07 00:00 [pmc-release]
AID - S1355617710000846 [pii]
AID - 10.1017/S1355617710000846 [doi]
PST - ppublish
SO  - J Int Neuropsychol Soc. 2010 Nov;16(6):1047-55. doi: 10.1017/S1355617710000846. 
      Epub 2010 Aug 25.