PMID- 2073594
OWN - NLM
STAT- MEDLINE
DCOM- 19910418
LR  - 20191210
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 534
IP  - 1-2
DP  - 1990 Nov 26
TI  - Persistent elevations in dopamine and its metabolites in the nucleus accumbens 
      after mild subchronic stress in rats with ibotenic acid lesions of the medial 
      prefrontal cortex.
PG  - 321-3
AB  - This study assessed the possible influence of the medial prefrontal cortex (MPFC) 
      on the response of subcortical dopamine (DA) systems to subchronic, mild stress. 
      DA and its metabolites as well as noradrenaline were assayed in the nucleus 
      accumbens and corpus striatum, 1 and 7 days after one week of daily 
      intraperitoneal saline injections (Stress) or no handling (No stress), in rats 
      with sham (Sham) or ibotenic acid (IA) lesions of the MPFC. One day after the 
      last saline injection the level of dihydroxyphenylacetic acid (DOPAC) was 
      elevated in the nucleus accumbens of IA/Stress rats in comparison to the Sham/No 
      stress, Sham/Stress, and IA/No Stress groups. Levels of mesolimbic DA, DOPAC and 
      homovanillic acid were still elevated 7 days after the last injection in 
      IA/Stress animals in comparison to all other groups. There were no other 
      significant differences between the groups. The data suggest that in rats with 
      MPFC impairment, mild subchronic stress can induce alterations in mesolimbic DA 
      activity that persist beyond the duration of the stress.
FAU - Jaskiw, G E
AU  - Jaskiw GE
AD  - Clinical Brain Disorders Branch, National Institute of Mental Health, NIMH 
      Neuroscience Center at St. Elizabeths, Washington, DC 20032.
FAU - Karoum, F K
AU  - Karoum FK
FAU - Weinberger, D R
AU  - Weinberger DR
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Catecholamines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 2552-55-8 (Ibotenic Acid)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Catecholamines/*metabolism
MH  - Cerebral Cortex/drug effects/pathology/*physiology
MH  - Dopamine/*metabolism
MH  - Handling, Psychological
MH  - Homovanillic Acid/metabolism
MH  - Ibotenic Acid/*toxicity
MH  - Male
MH  - Norepinephrine/metabolism
MH  - Nucleus Accumbens/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Stress, Psychological/*metabolism
EDAT- 1990/11/26 00:00
MHDA- 1990/11/26 00:01
CRDT- 1990/11/26 00:00
PHST- 1990/11/26 00:00 [pubmed]
PHST- 1990/11/26 00:01 [medline]
PHST- 1990/11/26 00:00 [entrez]
AID - 0006-8993(90)90149-6 [pii]
AID - 10.1016/0006-8993(90)90149-6 [doi]
PST - ppublish
SO  - Brain Res. 1990 Nov 26;534(1-2):321-3. doi: 10.1016/0006-8993(90)90149-6.