PMID- 20738945
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20190918
IS  - 1579-2242 (Electronic)
IS  - 0300-8932 (Linking)
VI  - 63
IP  - 8
DP  - 2010 Aug
TI  - Serum myostatin levels in chronic heart failure.
PG  - 992-6
AB  - Muscle wasting is common in advanced heart failure. Myostatin is an important 
      modulator of muscle catabolism. We measured serum levels of myostatin and its 
      propeptide in patients with chronic heart failure and analyzed their 
      relationships with clinical parameters and prognosis. The study included 70 
      patients: 30 in New York Heart Association (NYHA) functional class I-II and 40 in 
      class III-IV. Their mean ejection fraction was 32%+/-12%. The mean follow-up time 
      was 17.9+/-1.3 months. Thirteen patients (18.6%) died. No correlation was found 
      between myostatin and myostatin propeptide levels. Nor was the myostatin or 
      myostatin propeptide level correlated with age, sex, left ventricular ejection 
      fraction, symptom duration, or the level of N-terminal probrain natriuretic 
      peptide (NT-proBNP) or tumor necrosis factor-alpha receptor type-2 (TNFalpha R2). 
      Moreover, no relationship was observed between the myostatin or myostatin 
      propeptide level and NYHA functional class or mortality, in contrast to the 
      relationships found with NT-proBNP (P< .001 and P< .001, respectively) and 
      TNFalpha R2 (P=.001 and P=.005, respectively) levels. In conclusion, there was no 
      relationship between the myostatin or myostatin propeptide level and any 
      parameter of disease severity or prognosis in patients with chronic heart 
      failure.
FAU - Zamora, Elisabet
AU  - Zamora E
AD  - Unidad de Insuficiencia Cardiaca, Departamento de Medicina, Universidad Autonoma 
      de Barcelona, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, 
      Espana. e.zamora@telefonica.net
FAU - Simo, Rafael
AU  - Simo R
FAU - Lupon, Josep
AU  - Lupon J
FAU - Galan, Amparo
AU  - Galan A
FAU - Urrutia, Agustin
AU  - Urrutia A
FAU - Gonzalez, Beatriz
AU  - Gonzalez B
FAU - Mas, Dolores
AU  - Mas D
FAU - Valle, Vicente
AU  - Valle V
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - Rev Esp Cardiol
JT  - Revista espanola de cardiologia
JID - 0404277
RN  - 0 (Myostatin)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/*blood/diagnosis/mortality
MH  - Humans
MH  - Male
MH  - Myostatin/*blood
EDAT- 2010/08/27 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/08/27 06:00
PHST- 2010/08/27 06:00 [entrez]
PHST- 2010/08/27 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 13154091 [pii]
AID - 10.1016/s1885-5857(10)70194-8 [doi]
PST - ppublish
SO  - Rev Esp Cardiol. 2010 Aug;63(8):992-6. doi: 10.1016/s1885-5857(10)70194-8.