PMID- 20740276
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 213
IP  - 2-3
DP  - 2011 Feb
TI  - Serotonin 5-HT4 receptors in the nucleus accumbens are specifically involved in 
      the appetite suppressant and not locomotor stimulant effects of MDMA ('ecstasy').
PG  - 355-63
LID - 10.1007/s00213-010-1982-9 [doi]
AB  - RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA) abuse is a substantial 
      problem in young adults. Due to a high focus on body image in this population, 
      two main factors that may encourage MDMA use are the appetite suppressant and 
      locomotor stimulant effects of this drug. The nucleus accumbens (NAc) is a brain 
      region associated with the regulation of motivated and locomotor behaviours, and 
      recent evidence suggests that NAc 5-HT4 receptors are likely to be involved in 
      the appetite suppressant effect of MDMA. It has not yet been shown whether 5-HT4 
      receptors of the NAc are involved in the locomotor stimulant effects of MDMA, 
      which may also contribute to a reduction in food intake. OBJECTIVES: This study 
      aimed to investigate the effect of local antagonism of serotonin 5-HT4 receptors 
      in the NAc in the appetite suppressant and locomotor stimulant effects of MDMA. 
      METHODS: Male hooded Wistar rats underwent surgery for the implantation of 
      bilateral NAc microinjection cannulae under isofluorane anesthesia. Following 5-7 
      days of recovery, the rats received bilateral microinjections of the 5-HT4 
      antagonist RS39604 into the NAc immediately prior to either saline or MDMA 
      administration. Food intake, water intake, body weight and locomotor activity 
      were measured. RESULTS: RS39604 significantly increased food intake and increased 
      weight loss in MDMA-treated but not saline-treated rats. Measures of MDMA-induced 
      water intake or locomotor activity were not altered by antagonist administration. 
      CONCLUSIONS: These results demonstrate that 5-HT4 receptors in the NAc 
      specifically regulate the appetite suppressant effects of MDMA but not 
      MDMA-induced water intake or locomotor activity.
FAU - Francis, H M
AU  - Francis HM
AD  - Neuropharmacology Laboratory, Department of Psychology, Macquarie University, 
      Sydney, Australia.
FAU - Kraushaar, N J
AU  - Kraushaar NJ
FAU - Hunt, L R
AU  - Hunt LR
FAU - Cornish, J L
AU  - Cornish JL
LA  - eng
PT  - Journal Article
DEP - 20100826
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Appetite Depressants)
RN  - 0 (Piperidines)
RN  - 0 (RS 39604)
RN  - 0 (Serotonin 5-HT4 Receptor Antagonists)
RN  - 158165-40-3 (Receptors, Serotonin, 5-HT4)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - T75W9911L6 (Propane)
SB  - IM
MH  - Animals
MH  - Appetite Depressants/*pharmacology
MH  - Drinking/drug effects
MH  - Eating/drug effects
MH  - Male
MH  - Microinjections
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Nucleus Accumbens/drug effects/metabolism
MH  - Piperidines/pharmacology
MH  - Propane/analogs & derivatives/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Serotonin, 5-HT4/*drug effects/metabolism
MH  - Serotonin 5-HT4 Receptor Antagonists/pharmacology
MH  - Weight Loss/drug effects
EDAT- 2010/08/27 06:00
MHDA- 2011/05/25 06:00
CRDT- 2010/08/27 06:00
PHST- 2009/12/16 00:00 [received]
PHST- 2010/06/08 00:00 [accepted]
PHST- 2010/08/27 06:00 [entrez]
PHST- 2010/08/27 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.1007/s00213-010-1982-9 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2011 Feb;213(2-3):355-63. doi: 
      10.1007/s00213-010-1982-9. Epub 2010 Aug 26.