PMID- 20740586
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20141120
IS  - 1096-9098 (Electronic)
IS  - 0022-4790 (Linking)
VI  - 102
IP  - 3
DP  - 2010 Sep 1
TI  - Clinical outcomes of minimally invasive surgery using acridine orange for 
      musculoskeletal sarcomas around the forearm, compared with conventional limb 
      salvage surgery after wide resection.
PG  - 271-5
LID - 10.1002/jso.21602 [doi]
AB  - BACKGROUND AND OBJECTIVES: We recently developed and established a new surgical 
      therapy combining photodynamic surgery and radiodynamic therapy using acridine 
      orange (AO) therapy after marginal or intralesional tumor resection, providing 
      excellent limb function to sarcoma patients. The present study evaluated local 
      recurrence rate and limb function using Disability of Arm, Shoulder, and Hand 
      (DASH) score of patients with primary musculoskeletal sarcoma around the forearm 
      treated with AO therapy, compared to that of patients treated with conventional 
      wide resection. METHODS: Subjects were 18 patients with primary musculoskeletal 
      sarcoma around the forearm and treated with AO therapy (AO: n = 8) after marginal 
      or intralesional resection, or conventional wide resection followed by limb 
      reconstruction surgery (WR: n = 10). RESULTS: Mean age of the 18 patients was 45 
      years, and mean durations of follow-up for Groups AO and WR were 67 and 74.1 
      months. Local recurrence rates for AO and WR were 12.5% and 20% (P = 0.63), DASH 
      disability scores were 3.9 and 21 (P = 0.04), and 5-year survival rates were 100% 
      and 90% (P = 0.40), respectively. CONCLUSIONS: AO therapy offers maintenance of 
      excellent upper limb function and inhibition of local tumor recurrence, 
      representing a useful modality for limb salvage surgery in patients with sarcoma 
      around the forearm.
CI  - 2010 Wiley-Liss, Inc.
FAU - Matsubara, Takao
AU  - Matsubara T
AD  - Department of Orthopaedic Surgery, Mie Postgraduate School of Medicine, Tsu City, 
      Mie Prefecture, Japan.
FAU - Kusuzaki, Katsuyuki
AU  - Kusuzaki K
FAU - Matsumine, Akihiko
AU  - Matsumine A
FAU - Murata, Hiroaki
AU  - Murata H
FAU - Nakamura, Tomoki
AU  - Nakamura T
FAU - Uchida, Atsumasa
AU  - Uchida A
FAU - Sudo, Akihiro
AU  - Sudo A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Surg Oncol
JT  - Journal of surgical oncology
JID - 0222643
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/*therapeutic use
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Female
MH  - Forearm
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Limb Salvage/*methods
MH  - Male
MH  - Middle Aged
MH  - Minimally Invasive Surgical Procedures/*methods
MH  - Photochemotherapy
MH  - Sarcoma/*surgery
MH  - Treatment Outcome
EDAT- 2010/08/27 06:00
MHDA- 2010/09/17 06:00
CRDT- 2010/08/27 06:00
PHST- 2010/08/27 06:00 [entrez]
PHST- 2010/08/27 06:00 [pubmed]
PHST- 2010/09/17 06:00 [medline]
AID - 10.1002/jso.21602 [doi]
PST - ppublish
SO  - J Surg Oncol. 2010 Sep 1;102(3):271-5. doi: 10.1002/jso.21602.