PMID- 2079555
OWN - NLM
STAT- MEDLINE
DCOM- 19910502
LR  - 20211203
IS  - 0021-9975 (Print)
IS  - 0021-9975 (Linking)
VI  - 103
IP  - 4
DP  - 1990 Nov
TI  - Immunosuppression due to chronic ochratoxicosis in broiler chicks.
PG  - 399-410
AB  - Crystalline ochratoxin A (OA) was added to the feed of broiler chicks at 0.5 ppm 
      and 2.0 ppm, and humoral and cell-mediated immunity (CMI) were studied. CMI was 
      assessed by skin sensitivity testing, graft versus host (GVH) reaction and T 
      lymphocyte count. Humoral immunity was examined by measuring the haemagglutinin 
      (HA) response to sheep RBC (SRBC). In addition, total lymphocyte counts, total 
      serum protein, albumin and globulin were determined and the phagocytic activity 
      of splenic macrophages was measured in the nitroblue tetrazolium test (NBT). The 
      weights of lymphoid organs were also recorded at post-mortem examination of the 
      birds. Highly significant reductions in CMI were indicated by diminished skin 
      sensitivity, GVH reactions and T lymphocyte counts. On the other hand, only the 
      overall HA titres differed significantly between the various treatment groups. 
      Total lymphocyte counts, total serum protein, serum albumin and serum globulin 
      were significantly depressed on the 21st day of intoxication. The number of 
      NBT-positive cells was drastically reduced in both the intoxicated groups 
      compared with controls (P less than 0.05) and the weights of thymus, bursa of 
      Fabricius and spleen of intoxicated birds were significantly reduced. The study 
      illustrated the immunosuppressive effects of ochratoxicosis in broiler chicks.
FAU - Singh, G S
AU  - Singh GS
AD  - Department of Veterinary Pathology, Ranchi Veterinary College (B.A.U.), India.
FAU - Chauhan, H V
AU  - Chauhan HV
FAU - Jha, G J
AU  - Jha GJ
FAU - Singh, K K
AU  - Singh KK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
RN  - 0 (Blood Proteins)
RN  - 0 (Globulins)
RN  - 0 (Hemagglutinins)
RN  - 0 (Ochratoxins)
RN  - 0 (Serum Albumin)
RN  - 298-83-9 (Nitroblue Tetrazolium)
RN  - D241E059U6 (Dinitrofluorobenzene)
SB  - IM
MH  - Animals
MH  - Antibody Formation/drug effects
MH  - Blood Proteins/analysis
MH  - Cell Count/drug effects
MH  - Chickens
MH  - Chronic Disease
MH  - Dinitrofluorobenzene/pharmacology
MH  - Globulins/analysis
MH  - Graft vs Host Reaction/drug effects
MH  - Hemagglutinins/analysis
MH  - Immunity, Cellular/drug effects
MH  - *Immunosuppression Therapy
MH  - Macrophages/drug effects/pathology
MH  - Nitroblue Tetrazolium
MH  - Ochratoxins/*toxicity
MH  - Organ Size
MH  - Phagocytosis/drug effects
MH  - Poultry Diseases/chemically induced/*immunology
MH  - Serum Albumin/analysis
MH  - Spleen/anatomy & histology
MH  - T-Lymphocytes/pathology
MH  - Thymus Gland/anatomy & histology
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
AID - S0021-9975(08)80028-X [pii]
AID - 10.1016/s0021-9975(08)80028-x [doi]
PST - ppublish
SO  - J Comp Pathol. 1990 Nov;103(4):399-410. doi: 10.1016/s0021-9975(08)80028-x.