PMID- 20796268 OWN - NLM STAT- MEDLINE DCOM- 20101228 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 12 IP - 1 DP - 2010 Aug 26 TI - Accuracy of cardiovascular magnetic resonance in myocarditis: comparison of MR and histological findings in an animal model. PG - 49 LID - 10.1186/1532-429X-12-49 [doi] AB - BACKGROUND: Because endomyocardial biopsy has low sensitivity of about 20%, it can be performed near to myocardium that presented as late gadolinium enhancement (LGE) in cardiovascular magnetic resonance (CMR). However the important issue of comparing topography of CMR and histological findings has not yet been investigated. Thus the current study was performed using an animal model of myocarditis. RESULTS: In 10 male Lewis rats experimental autoimmune myocarditis was induced, 10 rats served as control. On day 21 animals were examined by CMR to compare topographic distribution of LGE to histological inflammation. Sensitivity, specificity, positive and negative predictive values for LGE in diagnosing myocarditis were determined for each segment of myocardium. Latter diagnostic values varied widely depending on topographic distribution of LGE and inflammation as well as on the used CMR sequence. Sensitivity of LGE was up to 76% (left lateral myocardium) and positive predictive values were up to 85% (left lateral myocardium), whereas sensitivity and positive predictive value dropped to 0-33% (left inferior myocardium). CONCLUSIONS: Topographic distribution of LGE and histological inflammation seem to influence sensitivity, specificity, positive and negative predictive values. Nevertheless, positive predictive value for LGE of up to 85% indicates that endomyocardial biopsy should be performed "MR-guided". LGE seems to have greater sensitivity than endomyocardial biopsy for the diagnosis of myocarditis. FAU - Korkusuz, Huedayi AU - Korkusuz H AD - Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. huedayi.korkusuz@kgu.de FAU - Esters, Philip AU - Esters P FAU - Huebner, Frank AU - Huebner F FAU - Bug, Reinhold AU - Bug R FAU - Ackermann, Hanns AU - Ackermann H FAU - Vogl, Thomas J AU - Vogl TJ LA - eng PT - Comparative Study PT - Journal Article DEP - 20100826 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 RN - 0 (Biomarkers) RN - 0 (Contrast Media) RN - 0 (Haptoglobins) RN - 0 (Troponin T) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Animals MH - Biomarkers/blood MH - *Biopsy MH - Contrast Media MH - Disease Models, Animal MH - Endocardium/metabolism/*pathology MH - Gadolinium DTPA MH - Haptoglobins/metabolism MH - *Magnetic Resonance Imaging MH - Male MH - Myocarditis/blood/*diagnosis/pathology MH - Predictive Value of Tests MH - Rats MH - Rats, Inbred Lew MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Severity of Illness Index MH - Time Factors MH - Troponin T/blood PMC - PMC2936396 EDAT- 2010/08/28 06:00 MHDA- 2010/12/29 06:00 PMCR- 2010/08/26 CRDT- 2010/08/28 06:00 PHST- 2010/04/11 00:00 [received] PHST- 2010/08/26 00:00 [accepted] PHST- 2010/08/28 06:00 [entrez] PHST- 2010/08/28 06:00 [pubmed] PHST- 2010/12/29 06:00 [medline] PHST- 2010/08/26 00:00 [pmc-release] AID - S1097-6647(23)01329-7 [pii] AID - 1532-429X-12-49 [pii] AID - 10.1186/1532-429X-12-49 [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2010 Aug 26;12(1):49. doi: 10.1186/1532-429X-12-49.