PMID- 20798271
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20211020
IS  - 1522-1601 (Electronic)
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 109
IP  - 6
DP  - 2010 Dec
TI  - Fatty diabetic lung: functional impairment in a model of metabolic syndrome.
PG  - 1913-9
LID - 10.1152/japplphysiol.00549.2010 [doi]
AB  - The Zucker diabetic fatty (ZDF fa/fa) rat with genetic leptin insensitivity 
      develops obesity and Type 2 diabetes mellitus (T2DM) with age accompanied by 
      hyperplastic changes in the distal lung (Am J Physiol Lung Cell Mol Physiol 298: 
      L392-L403, 2010). To determine the functional consequences of structural changes, 
      we developed a rebreathing (RB) technique to simultaneously measure lung volume, 
      pulmonary blood flow, lung diffusing capacity (Dl(CO)), membrane diffusing 
      capacity (Dm(CO)), pulmonary capillary blood volume (Vc), and septal tissue 
      volume in anesthetized tracheostomized male ZDF fa/fa and matched lean (+/+) 
      control animals at 4, 8, and 12 mo of age. Results obtained by RB technique were 
      compared with that measured by a single-breath (SB) technique and to that 
      expected in a wide range of species. In fa/fa animals compared with +/+, lung 
      volumes and compliance were 13-35% lower at different ages, and the normal 
      age-related increase in lung compliance was no longer evident. Mean pulmonary 
      blood flow declined with age in fa/fa but not in +/+ animals. Dl(CO) measured at 
      a given pulmonary blood flow was 20-43% lower at different ages due to reductions 
      in both Dm(CO) and Vc. Septal tissue volume was also reduced in older fa/fa rats. 
      We conclude that obese rats with T2DM develop significant restrictive pulmonary 
      defects with diffusion impairment in a pattern similar to that previously 
      reported in obese human subjects with T2DM. Functional impairment became 
      exaggerated with age and duration of T2DM. In both fa/fa and +/+ animals, Dl(CO) 
      measured by RB was systematically higher than by SB technique whereas lung volume 
      was similar, a finding consistent with heterogeneous distribution of ventilation 
      in the rat lung.
FAU - Yilmaz, Cuneyt
AU  - Yilmaz C
AD  - Department of Internal Medicine, Pulmonary and Critical Care Medicine, University 
      of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 
      75390-9034, USA.
FAU - Ravikumar, Priya
AU  - Ravikumar P
FAU - Bellotto, Dennis J
AU  - Bellotto DJ
FAU - Unger, Roger H
AU  - Unger RH
FAU - Hsia, Connie C W
AU  - Hsia CC
LA  - eng
GR  - R01 DK063242/DK/NIDDK NIH HHS/United States
GR  - DK-063242/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100826
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
SB  - IM
MH  - Age Factors
MH  - Aging
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*etiology/genetics
MH  - Disease Models, Animal
MH  - Hyperplasia
MH  - Lung/blood supply/pathology/*physiopathology
MH  - Lung Diseases/*etiology/genetics/pathology/physiopathology
MH  - Lung Volume Measurements
MH  - Male
MH  - Metabolic Syndrome/*etiology/genetics/pathology/physiopathology
MH  - Microcirculation
MH  - Obesity/*complications/genetics
MH  - Pulmonary Circulation
MH  - Pulmonary Diffusing Capacity
MH  - Rats
MH  - Rats, Zucker
MH  - Regional Blood Flow
MH  - Respiration, Artificial
MH  - Time Factors
MH  - Tracheostomy
PMC - PMC3006414
EDAT- 2010/08/28 06:00
MHDA- 2011/03/26 06:00
PMCR- 2011/12/01
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - japplphysiol.00549.2010 [pii]
AID - JAPPL-00549-2010 [pii]
AID - 10.1152/japplphysiol.00549.2010 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2010 Dec;109(6):1913-9. doi: 
      10.1152/japplphysiol.00549.2010. Epub 2010 Aug 26.