PMID- 20798662
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20151119
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Linking)
VI  - 43
IP  - 4
DP  - 2011 Apr
TI  - Markers of chronic inflammation with short-term changes in physical activity.
PG  - 578-83
LID - 10.1249/MSS.0b013e3181f59dc4 [doi]
AB  - PURPOSE: Regular exercise is inversely related to markers of chronic 
      inflammation, but we do not know to what extent these changes are the product of 
      recent exercise behavior. The aim of the present investigation was to examine the 
      stability of markers of chronic inflammation in the face of short-term positive 
      and negative changes in physical activity in middle-aged men. METHODS: Two 
      studies were conducted using a randomized counterbalanced design. In the first 
      study (Study 1), eight highly active men (age = 56 +/- 5 yr, body mass index (BMI) 
      = 23.3 +/- 3.2 kg.m(-2), VO(2max) = 50.7 +/- 7.0 mL.kg(-1).min(-1)) undertook two 
      trials; withdrawal of exercise for 1 wk versus control (normal exercise 
      behavior). In the second study (Study 2), 10 sedentary men (age = 57 +/- 2 yr, BMI 
      = 27.9 +/- 3.6 kg.m(-2), VO(2max) = 30.4 +/- 4.6 mL.kg(-1).min(-1)) undertook 30 min 
      of daily walking at 60% VO(2max) for 1 wk versus control (normal sedentary 
      behavior). RESULTS: The withdrawal of exercise for 1 wk in highly active men 
      (Study 1) and the imposition of 1 wk of daily exercise in sedentary men (Study 2) 
      did not elicit any substantial changes in the inflammatory proteins C-reactive 
      protein (CRP), IL-6, and TNF-alpha and circulating leukocyte concentration. The 
      differences in inflammatory proteins between active (Study 1) and sedentary 
      (Study 2) men were marked; for example, baseline CRP was 0.85 +/- 0.79 and 3.02 +/- 
      2.30 mg.L(-1), respectively. CONCLUSIONS: The inflammatory markers CRP, IL-6, and 
      TNF-alpha are stable and not affected by large short-term positive or negative 
      alterations in exercise behavior. This stability strengthens the use of these 
      markers in clinical and research settings because differences and changes are not 
      simply the product of recent exercise behavior.
FAU - Lund, Adam J S
AU  - Lund AJ
AD  - Department for Health, University of Bath, Bath, United Kingdom.
FAU - Hurst, Tina L
AU  - Hurst TL
FAU - Tyrrell, Rex M
AU  - Tyrrell RM
FAU - Thompson, Dylan
AU  - Thompson D
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Anthropometry
MH  - Biomarkers
MH  - C-Reactive Protein/*analysis
MH  - Chronic Disease
MH  - Cytokines/*blood
MH  - Humans
MH  - Inflammation/blood/etiology/*metabolism
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Motor Activity/*immunology
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2010/08/28 06:00
MHDA- 2011/07/30 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1249/MSS.0b013e3181f59dc4 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2011 Apr;43(4):578-83. doi: 10.1249/MSS.0b013e3181f59dc4.