PMID- 20800057
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20220408
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 43
IP  - 16-17
DP  - 2010 Nov
TI  - Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased 
      risk of micro- and macro-albuminuria and progression of diabetic nephropathy 
      among Iranians with type 2 diabetes mellitus.
PG  - 1333-9
LID - 10.1016/j.clinbiochem.2010.08.019 [doi]
AB  - OBJECTIVES: To find whether polymorphisms of methylenetetrahydrofolate reductase 
      (MTHFR) C677T and A1298C are risk factors for diabetic nephropathy (DN) among 
      type 2 diabetes mellitus (T2DM) patients from Western Iran. DESIGN AND METHODS: 
      The MTHFR polymorphisms were detected in 72 microalbuminuric, 68 macroalbuminuric 
      and 72 normoalbuinuric T2DM patients by PCR-RFLP. RESULTS: The possession of both 
      MTHFR 677T and 1298C alleles increase the risk of microalbuminuria to 4.3-fold 
      (p=0.007) in T2DM patients. The presence of either MTHFR 677T, 1298C allele is 
      sufficient to increase the risk of macroalbuminuria in T2DM patients by 4.1 and 
      5.5 times (p=0.027, and p=0.006, respectively). The concomitant presence of both 
      677T and 1298C alleles act in synergy to increase the risk of macroalbuminuria by 
      20.4-fold (p<0.001) and progression of DN from microalbuminuria to 
      macroalbuminuria (OR=4.73, p=0.01). CONCLUSION: Both MTHFR 677T and 1298C alleles 
      increased the susceptibility to the onset and progression of DN in Iranians with 
      T2DM.
CI  - Copyright (c) 2010. Published by Elsevier Inc.
FAU - Rahimi, Mehrali
AU  - Rahimi M
AD  - Department of Endocrinology, Medical School, Kermanshah University of Medical 
      Sciences, Kermanshah, Iran.
FAU - Hasanvand, Ali
AU  - Hasanvand A
FAU - Rahimi, Zohreh
AU  - Rahimi Z
FAU - Vaisi-Raygani, Asad
AU  - Vaisi-Raygani A
FAU - Mozafari, Hadi
AU  - Mozafari H
FAU - Rezaei, Mansour
AU  - Rezaei M
FAU - Zargooshi, Javad
AU  - Zargooshi J
FAU - Najafi, Farid
AU  - Najafi F
FAU - Shakiba, Ebrahim
AU  - Shakiba E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100825
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Albuminuria/complications/enzymology/*genetics
MH  - Alleles
MH  - Amino Acid Substitution/genetics
MH  - Demography
MH  - Diabetes Mellitus, Type 2/*complications/enzymology/genetics
MH  - Diabetic Nephropathies/complications/enzymology/*genetics
MH  - *Disease Progression
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Predisposition to Disease
MH  - Heterozygote
MH  - Humans
MH  - Iran
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Risk Factors
EDAT- 2010/08/31 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/04/22 00:00 [received]
PHST- 2010/08/11 00:00 [revised]
PHST- 2010/08/14 00:00 [accepted]
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - S0009-9120(10)00379-6 [pii]
AID - 10.1016/j.clinbiochem.2010.08.019 [doi]
PST - ppublish
SO  - Clin Biochem. 2010 Nov;43(16-17):1333-9. doi: 10.1016/j.clinbiochem.2010.08.019. 
      Epub 2010 Aug 25.