PMID- 20800616
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1872-9711 (Electronic)
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 31
IP  - 6
DP  - 2010 Dec
TI  - MDMA administration decreases serotonin but not N-acetylaspartate in the rat 
      brain.
PG  - 654-61
LID - 10.1016/j.neuro.2010.08.005 [doi]
AB  - In animals, repeated administration of 3,4-methylenedioxymethamphetamine (MDMA) 
      reduces markers of serotonergic activity and studies show similar serotonergic 
      deficits in human MDMA users. Using proton-magnetic resonance spectroscopy 
      ((1)H-MRS) at 11.7Tesla, we measured the metabolic neurochemical profile in 
      intact, discrete tissue punches taken from prefrontal cortex, anterior striatum, 
      and hippocampus of rats administered MDMA (5mg/kg IP, 4x q 2h) or saline and 
      euthanized 7 days after the last injection. Monoamine content was measured with 
      HPLC in contralateral punches from striatum and hippocampus to compare the 
      MDMA-induced loss of 5HT innervation with constituents in the (1)H-MRS profile. 
      When assessed 7 days after the last MDMA injection, levels of hippocampal and 
      striatal serotonin (5HT) were significantly reduced, consistent with published 
      animal studies. N-Acetylaspartate (NAA) levels were significantly increased in 
      prefrontal cortex and not affected in anterior striatum or hippocampus; 
      myo-inositol (INS) levels were increased in prefrontal cortex and hippocampus but 
      not anterior striatum. Glutamate levels were increased in prefrontal cortex and 
      decreased in hippocampus, while GABA levels were decreased only in hippocampus. 
      The data suggest that NAA may not reliably reflect MDMA-induced 5HT 
      neurotoxicity. However, the collective pattern of changes in 5HT, INS, glutamate 
      and GABA is consistent with persistent hippocampal neuroadaptations caused by 
      MDMA.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Perrine, Shane A
AU  - Perrine SA
AD  - Department of Psychiatry and Behavioral Neurosciences, Brain Research and Imaging 
      Neuroscience Division, Wayne State University School of Medicine, Detroit, MI 
      48201, USA. sperrine@med.wayne.edu
FAU - Ghoddoussi, Farhad
AU  - Ghoddoussi F
FAU - Michaels, Mark S
AU  - Michaels MS
FAU - Hyde, Elisabeth M
AU  - Hyde EM
FAU - Kuhn, Donald M
AU  - Kuhn DM
FAU - Galloway, Matthew P
AU  - Galloway MP
LA  - eng
GR  - K01-DA024760/DA/NIDA NIH HHS/United States
GR  - R01 DA016736/DA/NIDA NIH HHS/United States
GR  - K01 DA024760-02/DA/NIDA NIH HHS/United States
GR  - K01 DA024760/DA/NIDA NIH HHS/United States
GR  - R01-DA016736/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100826
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Serotonin Antagonists)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 997-55-7 (N-acetylaspartate)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/*analogs & derivatives/metabolism
MH  - Brain/*drug effects/*metabolism
MH  - Brain Chemistry/*drug effects/physiology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Serotonin Antagonists/*toxicity
PMC - PMC2974051
MID - NIHMS232135
EDAT- 2010/08/31 06:00
MHDA- 2011/10/01 06:00
PMCR- 2011/12/01
CRDT- 2010/08/31 06:00
PHST- 2009/06/10 00:00 [received]
PHST- 2010/06/09 00:00 [revised]
PHST- 2010/08/18 00:00 [accepted]
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - S0161-813X(10)00174-9 [pii]
AID - 10.1016/j.neuro.2010.08.005 [doi]
PST - ppublish
SO  - Neurotoxicology. 2010 Dec;31(6):654-61. doi: 10.1016/j.neuro.2010.08.005. Epub 
      2010 Aug 26.