PMID- 20802469
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Linking)
VI  - 23
IP  - 12
DP  - 2010 Dec
TI  - Detection of chromosome copy number alterations in metanephric adenomas by array 
      comparative genomic hybridization.
PG  - 1634-40
LID - 10.1038/modpathol.2010.162 [doi]
AB  - Metanephric adenoma is a rare benign renal tumor typically found in adults. 
      Previous cytogenetic analyses, including karyotyping, fluorescence in situ 
      hybridization (FISH), and comparative genomic hybridization, have yielded 
      conflicting results regarding the somatic genetic aberrations of these tumors. In 
      this study, we investigated the genomic profile of nine cases of metanephric 
      adenoma using array comparative genomic hybridization. Two cases revealed 
      multiple chromosomal gains and losses. Three cases showed sporadic chromosomal 
      imbalances involving no more than three chromosomes. Four cases showed normal 
      chromosome copy numbers. The gain of chromosome 19 was the most common finding 
      (five cases), and FISH using 19p and 19q telomeric probes further confirmed this 
      finding. We did not observe consistent gains of chromosomes 7 and 17, which are 
      common in papillary renal cell carcinoma, neither did we find chromosomal 
      alterations frequently present in Wilms' tumors, including chromosome gains of 
      1q, 7q, and 12, and losses of 11p and 16q. Our series demonstrates that the 
      genetic profile of metanephric adenoma is fundamentally distinct from those of 
      papillary renal cell carcinoma and Wilms' tumor.
FAU - Pan, Chin-Chen
AU  - Pan CC
AD  - Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan. 
      ccpan@vghtpe.gov.tw
FAU - Epstein, Jonathan I
AU  - Epstein JI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100827
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
SB  - IM
MH  - Adenoma/*genetics
MH  - Adult
MH  - Comparative Genomic Hybridization
MH  - Female
MH  - Gene Dosage
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 2010/08/31 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - S0893-3952(22)02618-7 [pii]
AID - 10.1038/modpathol.2010.162 [doi]
PST - ppublish
SO  - Mod Pathol. 2010 Dec;23(12):1634-40. doi: 10.1038/modpathol.2010.162. Epub 2010 
      Aug 27.