PMID- 20803086
OWN - NLM
STAT- MEDLINE
DCOM- 20110520
LR  - 20240204
IS  - 0219-1032 (Electronic)
IS  - 1016-8478 (Linking)
VI  - 30
IP  - 3
DP  - 2010 Sep
TI  - MKP1 regulates the induction of MCP1 by Streptococcus pneumoniae pneumolysin in 
      human epithelial cells.
PG  - 263-70
LID - 10.1007/s10059-010-0113-0 [doi]
AB  - Epithelial cells act as the first line of host defense against microbes by 
      producing a range of different molecules for clearance. Chemokines facilitate the 
      clearance of invaders through the recruitment of leukocytes. Thus, upregulation 
      of chemokine expression represents an important innate host defense response 
      against invading microbes such as Streptococcus pneumoniae. In this study, we 
      report that the expression of Monocyte Chemotactic Protein 1 (MCP1) was highly 
      induced in response to S. pneumoniae in vitro and in vivo. Among numerous 
      virulence factors, pneumococcal pneumolysin was found to be the major factor 
      responsible for this induction. Furthermore, MCP1 induction was mediated by the 
      p38 mitogen-activated protein kinase (MAPK) whose activation was controlled by 
      MAPK phosphatase 1 (MKP1). Therefore, this study reveals novel roles of 
      pneumolysin in mediating MKP1 expression for the regulation of MCP1 expression in 
      human epithelial cells.
FAU - Shin, Hee-Sung
AU  - Shin HS
AD  - Department of Biotechnology and Bioinformatics, Korea University, Yeongi, 
      339-700, Korea.
FAU - Yoo, In-Hwa
AU  - Yoo IH
FAU - Kim, Yong-Jae
AU  - Kim YJ
FAU - Lee, Ji-Yun
AU  - Lee JY
FAU - Kim, Hyong-Bai
AU  - Kim HB
FAU - Jin, Shouguang
AU  - Jin S
FAU - Ha, Un-Hwan
AU  - Ha UH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100823
PL  - United States
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
RN  - 0 (Bacterial Proteins)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Streptolysins)
RN  - 0 (plY protein, Streptococcus pneumoniae)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 3.1.3.48 (Dual Specificity Phosphatase 1)
SB  - IM
MH  - Animals
MH  - Bacterial Proteins/metabolism
MH  - Cell Line
MH  - Chemokine CCL2/genetics/immunology/*metabolism
MH  - Dual Specificity Phosphatase 1/*metabolism
MH  - Epithelial Cells/immunology/*metabolism/microbiology/pathology
MH  - Gene Expression Regulation
MH  - Humans
MH  - Immunity, Innate
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - RNA, Small Interfering/genetics
MH  - Streptococcal Infections/genetics/immunology/*metabolism
MH  - Streptococcus pneumoniae/*immunology/pathogenicity
MH  - Streptolysins/metabolism
MH  - Virulence
MH  - p38 Mitogen-Activated Protein Kinases/genetics/metabolism
EDAT- 2010/08/31 06:00
MHDA- 2011/05/21 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/05/03 00:00 [received]
PHST- 2010/06/04 00:00 [accepted]
PHST- 2010/06/03 00:00 [revised]
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/05/21 06:00 [medline]
AID - S1016-8478(23)11508-1 [pii]
AID - 10.1007/s10059-010-0113-0 [doi]
PST - ppublish
SO  - Mol Cells. 2010 Sep;30(3):263-70. doi: 10.1007/s10059-010-0113-0. Epub 2010 Aug 
      23.