PMID- 20803773
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20211020
IS  - 1862-1783 (Electronic)
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 11
IP  - 9
DP  - 2010 Sep
TI  - Is short-term therapy really sufficient to eradicate Helicobacter pylori 
      infection?
PG  - 690-701
LID - 10.1631/jzus.B1000008 [doi]
AB  - OBJECTIVE: The aim of our study was to perform a systematic review and 
      meta-analysis of the efficacy of short-term protocols for Helicobacter pylori 
      eradication and to review the safety and adverse profiles of these eradication 
      protocols. METHODS: Literatures were located through electronic searches by 
      PubMed, Medline, ISI Web of Knowledge, and Cochrane Library using the relevant 
      terms. Abstracts of important meetings were searched manually in some journal 
      supplements. Additional bibliographies were identified from the reference lists 
      of identified studies. Three independent reviewers systemically identified 
      randomized controlled trials (RCTs) comparing short-duration protocols vs. 7-d 
      proton pump inhibitor (PPI)-based triple protocols, as well as studies reporting 
      eradication rates of short-duration protocols for H. pylori. Summary effect size 
      was calculated as relative risk (RR) and 95% confidence intervals (CI) using 
      Review Manager 4.2, and P<0.05 was defined as statistically significant in all 
      analyses. RESULTS: Among 90 abstracts retrieved, 15 studies were analyzed, 
      including a total of 30 treatment regimens with 1856 subjects. Mean 
      intention-to-treat (ITT) cure rates of 63.2% and 81.3% were achieved with 
      short-term protocols and 7-d PPI-containing protocols, respectively. Per-protocol 
      (PP)-based overall cure rates were 66.6% and 86.1%, respectively. Short-term 
      therapy was inferior to 7-d triple regimen (P<0.00001). After sub-analysis, 
      however, comparing the effects of > or = 3-d protocols and 7-d triple protocols, 
      the cumulative ITT RR was 0.95 (P=0.26), and PP RR was 0.95 (P=0.10), without 
      significant heterogeneity. Moreover, slightly fewer adverse-effects were found in 
      short-term protocols. CONCLUSIONS: Although more economical, short-duration 
      protocols are inferior to 7-d PPI-based triple protocols with regarding to 
      eradication rate of H. pylori. Protocols of more than 3 d, however, may be 
      equivalent to 7-d protocols.
FAU - Zhou, Ning
AU  - Zhou N
AD  - Department of Gastroenterology, the First Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou 310003, China.
FAU - Chen, Wei-xing
AU  - Chen WX
FAU - Zhang, Wei
AU  - Zhang W
FAU - Li, Lan
AU  - Li L
FAU - Jin, Xi
AU  - Jin X
FAU - Li, You-ming
AU  - Li YM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Bacterial Agents/administration & dosage/adverse 
      effects/*pharmacology/therapeutic use
MH  - Drug Therapy, Combination
MH  - Helicobacter Infections/*drug therapy
MH  - Helicobacter pylori/*growth & development
MH  - Humans
MH  - Proton Pump Inhibitors/administration & dosage/adverse 
      effects/*pharmacology/therapeutic use
MH  - *Randomized Controlled Trials as Topic
PMC - PMC2932879
EDAT- 2010/08/31 06:00
MHDA- 2011/01/05 06:00
PMCR- 2010/09/01
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - 10.1631/jzus.B1000008 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2010 Sep;11(9):690-701. doi: 10.1631/jzus.B1000008.