PMID- 20804201
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20181201
IS  - 1526-4602 (Electronic)
IS  - 1525-7797 (Linking)
VI  - 11
IP  - 10
DP  - 2010 Oct 11
TI  - Synthesis and characterization of amphiphilic lipopolymers for micellar drug 
      delivery.
PG  - 2610-20
LID - 10.1021/bm100561v [doi]
AB  - The objective of this study was to design lipopolymers for hydrophobic drug 
      delivery. Poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene 
      carbonate-graft-dodecanol) (PEG-PCD) lipopolymers were synthesized and 
      characterized by (1)H NMR, FT-IR, GPC, and DSC. The critical micelle 
      concentration (CMC) of PEG-PCD micelles was around 10(-8) M and decreased with 
      increasing length of hydrophobic block. PEG-PCD micelles could efficiently load a 
      model drug embelin into its hydrophobic core and significantly improve its 
      solubility. The loading capacity was dependent on the polymer core structure, but 
      the length of hydrophobic core had little effect. PEG-PCD formed both spherical 
      and cylindrical micelles, which were dependent on the copolymer structure and 
      composition. PEG-PCD lipopolymers with various hydrophobic core lengths showed 
      similar drug release profiles, which were slower than that of poly(ethylene 
      glycol)-block-poly(2-methyl-2-benzoxycarbonyl-propylene carbonate) (PEG-PBC) 
      micelles. Embelin loaded PEG-PCD micelles showed significant inhibition of C4-2 
      prostate cancer cell proliferation, while no obvious cellular toxicity was 
      observed for blank micelles.
FAU - Li, Feng
AU  - Li F
AD  - Department of Pharmaceutical Sciences, University of Tennessee Health Science 
      Center, Memphis, TN 38103, USA.
FAU - Danquah, Michael
AU  - Danquah M
FAU - Mahato, Ram I
AU  - Mahato RI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Benzoquinones)
RN  - 0 (Drug Carriers)
RN  - 0 (Micelles)
RN  - 0 (Polyesters)
RN  - 0 (Surface-Active Agents)
RN  - 0 (poly(ethylene glycol)-block-poly(2-methyl-2-carboxylpropylene 
      carbonate-graft-dodecanol))
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - SHC6U8F5ER (embelin)
SB  - IM
MH  - Antineoplastic Agents/administration & dosage/pharmacology
MH  - Benzoquinones/administration & dosage/pharmacology
MH  - Calorimetry, Differential Scanning
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Chromatography, Gel
MH  - Drug Carriers/*chemical synthesis/chemistry
MH  - Humans
MH  - Male
MH  - Micelles
MH  - Microscopy, Electron, Transmission
MH  - Particle Size
MH  - Polyesters/*chemical synthesis/chemistry
MH  - Polyethylene Glycols/*chemical synthesis/chemistry
MH  - Polymerization
MH  - Prostatic Neoplasms
MH  - Solubility
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Surface Properties
MH  - Surface-Active Agents/*chemical synthesis/chemistry
EDAT- 2010/09/02 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/09/01 06:00
PHST- 2010/09/01 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 10.1021/bm100561v [doi]
PST - ppublish
SO  - Biomacromolecules. 2010 Oct 11;11(10):2610-20. doi: 10.1021/bm100561v.