PMID- 20804596
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20211203
IS  - 1423-0127 (Electronic)
IS  - 1021-7770 (Print)
IS  - 1021-7770 (Linking)
VI  - 17 Suppl 1
IP  - Suppl 1
DP  - 2010 Aug 24
TI  - Low cardiovascular risks in the middle aged males and females excreting greater 
      24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the 
      world.
PG  - S21
LID - 10.1186/1423-0127-17-S1-S21 [doi]
AB  - BACKGROUND: Since taurine (T) administration was proven to decrease blood 
      pressure (BP) and stroke mortality in stroke-prone spontaneously hypertension 
      rates (SHRSP) in the 1980's and our WHO-coordinated CARDIAC (Cardiovascular 
      Diseases and Alimentary Comparison) Study demonstrated that among 5 diet-related 
      factors, namely total cholesterol (T-Cho), body mass index (BMI), sodium (Na), 
      magnesium (M), and T to creatinine (Cr) ratio in 24-hour urine (24U), both T/Cr 
      and M/Cr were inversely related to coronary heart disease mortalities in males 
      and females and T/Cr was inversely related to stroke mortalities in males and 
      females. We further analyzed the associations of individual T/Cr and M/Cr levels 
      to cardiovascular risks in the present study. METHOD: From WHO-CARDIAC Study 
      populations, 61 populations of 25 countries in the world, Japanese populations 
      with obviously higher 24U T excretion because of their common fish eating custom 
      and the other populations in which both data of T and M were not available were 
      excluded and the data of 3960 individuals from 41 WHO-CARDIAC Study populations 
      were used for the following analyses. RESULTS: The means of 24U T/Cr and M/Cr 
      ratios in total individual data were 639.4 and 82.8, respectively. The average of 
      BMI, systolic and diastolic blood pressure (SBP, DBP), T-Cho and atherogenic 
      index (AI) in the individuals with more than the means of T/Cr or M/Cr were 
      significantly lower than those of individuals with less than the means. The 
      CARDIAC Study participants were divided into the following 4 groups by these 
      means: A (T/Cr and M/Cr > or = mean), B (T/Cr > or = mean, M/Cr < mean), C (T/Cr 
      < mean, M/Cr > or = mean), D (T/Cr and M/Cr < mean). The group A showed 
      significantly lower values compared with the group D in BMI, SBP, DBP, T-Cho, and 
      AI. CONCLUSIONS: Cardiovascular risks were proven to be highly significantly 
      lower in individuals who were excreting both 24U T and M, more than the averages 
      despite differences in ethnicity and genetic background. Since T and M are 
      biomarkers for seafood, vegetables, soy, nuts, milk, etc., dietary custom to eat 
      these food sources could be recommended for cardiovascular disease prevention.
FAU - Yamori, Yukio
AU  - Yamori Y
AD  - Mukogawa Women's University Institute for World Health Development, Nishinomiya, 
      Hyogo, 6638143, Japan. yamori@cardiacstudy.com
FAU - Taguchi, Takashi
AU  - Taguchi T
FAU - Mori, Hideki
AU  - Mori H
FAU - Mori, Mari
AU  - Mori M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100824
PL  - England
TA  - J Biomed Sci
JT  - Journal of biomedical science
JID - 9421567
RN  - 1EQV5MLY3D (Taurine)
RN  - AYI8EX34EU (Creatinine)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Blood Pressure/physiology
MH  - Body Mass Index
MH  - Cardiovascular Diseases/physiopathology/prevention & control/*urine
MH  - Creatinine/urine
MH  - *Diet
MH  - *Ethnicity
MH  - Female
MH  - Humans
MH  - Magnesium/*urine
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Taurine/*urine
MH  - World Health Organization
PMC - PMC2994377
EDAT- 2010/09/11 06:00
MHDA- 2011/02/02 06:00
PMCR- 2010/08/24
CRDT- 2010/09/01 06:00
PHST- 2010/09/01 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
PHST- 2010/08/24 00:00 [pmc-release]
AID - 1423-0127-17-S1-S21 [pii]
AID - 10.1186/1423-0127-17-S1-S21 [doi]
PST - epublish
SO  - J Biomed Sci. 2010 Aug 24;17 Suppl 1(Suppl 1):S21. doi: 
      10.1186/1423-0127-17-S1-S21.