PMID- 20805013
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20131121
IS  - 1768-3254 (Electronic)
IS  - 0223-5234 (Linking)
VI  - 45
IP  - 11
DP  - 2010 Nov
TI  - Poly propyl ether imine (PETIM) dendrimer: a novel non-toxic dendrimer for 
      sustained drug delivery.
PG  - 4997-5005
LID - 10.1016/j.ejmech.2010.08.006 [doi]
AB  - In the present study, an attempt was made to study the acute and sub-acute 
      toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its 
      use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer 
      complex was prepared and characterized by FTIR, solubility and in vitro drug 
      release study. PETIM dendrimer was found to have significantly less toxicity in 
      A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 
      days sub-acute toxicity measurement in mice showed no mortality, hematological, 
      biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. 
      The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a 
      safe and efficient vehicle for sustained drug delivery.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Jain, Subheet
AU  - Jain S
AD  - Department of Pharmaceutical Sciences and Drug Research, Punjabi University, 
      Patiala 147002, India. subheetjain@rediffmail.com
FAU - Kaur, Amanpreet
AU  - Kaur A
FAU - Puri, Richa
AU  - Puri R
FAU - Utreja, Puneet
AU  - Utreja P
FAU - Jain, Anubhuti
AU  - Jain A
FAU - Bhide, Mahesh
AU  - Bhide M
FAU - Ratnam, Rakesh
AU  - Ratnam R
FAU - Singh, Vinay
AU  - Singh V
FAU - Patil, A S
AU  - Patil AS
FAU - Jayaraman, N
AU  - Jayaraman N
FAU - Kaushik, Gaurav
AU  - Kaushik G
FAU - Yadav, Subodh
AU  - Yadav S
FAU - Khanduja, K L
AU  - Khanduja KL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100812
PL  - France
TA  - Eur J Med Chem
JT  - European journal of medicinal chemistry
JID - 0420510
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Dendrimers)
RN  - 0 (Drug Carriers)
RN  - 90Y4QC304K (Ketoprofen)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage
MH  - Cell Line
MH  - Chromatography, High Pressure Liquid
MH  - Dendrimers/*administration & dosage/*chemistry
MH  - *Drug Carriers
MH  - Female
MH  - Humans
MH  - Ketoprofen/administration & dosage
MH  - Male
MH  - Mice
MH  - Spectrophotometry, Infrared
EDAT- 2010/09/02 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/09/01 06:00
PHST- 2010/01/06 00:00 [received]
PHST- 2010/08/04 00:00 [revised]
PHST- 2010/08/06 00:00 [accepted]
PHST- 2010/09/01 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - S0223-5234(10)00570-2 [pii]
AID - 10.1016/j.ejmech.2010.08.006 [doi]
PST - ppublish
SO  - Eur J Med Chem. 2010 Nov;45(11):4997-5005. doi: 10.1016/j.ejmech.2010.08.006. 
      Epub 2010 Aug 12.