PMID- 20805175
OWN - NLM
STAT- MEDLINE
DCOM- 20101013
LR  - 20220318
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
VI  - 65
IP  - 9
DP  - 2010 Sep
TI  - Prediction of asthma in symptomatic preschool children using exhaled nitric 
      oxide, Rint and specific IgE.
PG  - 801-7
LID - 10.1136/thx.2009.126912 [doi]
AB  - RATIONALE: For clinicians it remains very difficult to predict whether preschool 
      children with symptoms suggestive of asthma will develop asthma in later 
      childhood. OBJECTIVE: To investigate whether measurement of fraction of exhaled 
      nitric oxide (FE(NO)), interrupter resistance (Rint) or specific immunoglobulin E 
      (IgE) in 4-year-old children with suggestive symptoms can predict asthma symptoms 
      up to age 8 years. METHODS: Children were recruited from the PIAMA birth cohort. 
      All children with symptoms suggestive of asthma at age 3 or 4 years, who were 
      invited for medical examination at age 4 (n=848), were eligible. Associations of 
      FE(NO) (n=308), Rint (n=482) and specific IgE (n=380) at 4 years with wheezing 
      and asthma at the ages of 5-8 years were assessed using repeated measurement 
      analyses. The added predictive value of these objective tests was then 
      investigated by including parameters for clinical history in the model. RESULTS: 
      FE(NO) and specific IgE measured at 4 years were associated with wheezing and 
      asthma at 8 years. Both tests also remained significant predictors after mutual 
      adjustment and adjustment for clinical history: OR on wheezing at 8 years for 
      FE(NO) ((10)log-scale, per IQR) 1.6 (95% CI 1.1 to 2.2) and for specific IgE 2.8 
      (95% CI 1.9 to 4.1). Rint was significantly associated with wheezing at age 6, 
      but not at 7 and 8 years. CONCLUSIONS: In preschool children with symptoms 
      suggestive of asthma, both FE(NO) and specific IgE measured at age 4, but not 
      Rint, improved the prediction of asthma symptoms until the age of 8 years, 
      independent of clinical history.
FAU - Caudri, Daan
AU  - Caudri D
AD  - Department of Pediatrics/Respiratory Medicine, Erasmus University, Rotterdam, The 
      Netherlands.
FAU - Wijga, Alet H
AU  - Wijga AH
FAU - Hoekstra, Maarten O
AU  - Hoekstra MO
FAU - Kerkhof, Marjan
AU  - Kerkhof M
FAU - Koppelman, Gerard H
AU  - Koppelman GH
FAU - Brunekreef, Bert
AU  - Brunekreef B
FAU - Smit, Henriette A
AU  - Smit HA
FAU - de Jongste, Johan C
AU  - de Jongste JC
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
RN  - 0 (Biomarkers)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Airway Resistance/*physiology
MH  - Asthma/*diagnosis
MH  - Biomarkers/metabolism
MH  - Breath Tests/methods
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Male
MH  - Nitric Oxide/*metabolism
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Respiratory Sounds/diagnosis
EDAT- 2010/09/02 06:00
MHDA- 2010/10/14 06:00
CRDT- 2010/09/01 06:00
PHST- 2010/09/01 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2010/10/14 06:00 [medline]
AID - 65/9/801 [pii]
AID - 10.1136/thx.2009.126912 [doi]
PST - ppublish
SO  - Thorax. 2010 Sep;65(9):801-7. doi: 10.1136/thx.2009.126912.